(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

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Chemical Name:(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol
CAS No.:81470-85-1
Molecular Formula:C₂₉H₄₄O₄Si
Molecular Weight:484.751
Hs Code.:

Synonyms:(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

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Chemical Property of (R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

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Technology Process of (R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

There total 34 articles about (R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 81479-08-5
2,2-Dimethyl-propionic acid (R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propyl ester

: 81470-85-1,110455-58-8,115115-17-8,122292-25-5
(R)-2-{(4S,5R,6S)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 25 ℃; for 0.25h;
DOI:10.1016/S0040-4020(01)93261-2

Reference yield:

: 207226-56-0
{(R)-2-[(4R,5R,6R)-6-((R)-2-Benzyloxy-1-methyl-ethyl)-2,2,5-trimethyl-[1,3]dioxan-4-yl]-propoxy}-tert-butyl-diphenyl-silane

: 81470-85-1
(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 17h;
DOI:10.1021/jo980137w

Reference yield:

: 170899-15-7
Acetic acid (4S,5S,6R)-7-benzyloxy-5-hydroxy-4,6-dimethyl-hept-2-ynyl ester

: 81470-85-1
(R)-2-{(4R,5R,6R)-6-[(R)-2-(tert-Butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-propan-1-ol

Guidance literature:: Multi-step reaction with 8 steps

2: 65 percent / Red-Al / tetrahydrofuran / 48 h / 0 - 20 °C

3: 83 percent / (+)-DIPT, Ti(O-i-Pr)4, t-BuOOH / CH₂Cl₂ / 18 h / -25 °C

4: 72 percent / CuCN / tetrahydrofuran / 1.) -78 deg C to 0 deg C, 30 min, 2.) 36 h

6: imidazole / dimethylformamide / 18 h / 0 - 20 °C

7: CSA / 3 h / Ambient temperature

8: H₂ / 5percent Pd/C / ethyl acetate / 17 h

With 1H-imidazole; titanium(IV) isopropylate; tert.-butylhydroperoxide; L-(+)-diisopropyl tartrate; camphor-10-sulfonic acid; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo980137w