C₂₁H₂₁F₂NO₂

Base Information

Chemical Name:C₂₁H₂₁F₂NO₂
CAS No.:1292820-68-8
Molecular Formula:C₂₁H₂₁F₂NO₂
Molecular Weight:357.4
Hs Code.:

C<sub>21</sub>H<sub>21</sub>F<sub>2</sub>NO<sub>2</sub>

Synonyms:C₂₁H₂₁F₂NO₂

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Chemical Property of C₂₁H₂₁F₂NO₂

Chemical Property:

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Technology Process of C₂₁H₂₁F₂NO₂

There total 3 articles about C₂₁H₂₁F₂NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 61550-02-5
(furan-2-yloxy)-trimethylsilane

: 1292820-58-6
C₁₇H₁₇F₂N

: 1292820-68-8
C₂₁H₂₁F₂NO₂

Guidance literature:: (furan-2-yloxy)-trimethylsilane; C₁₇H₁₇F₂N; With ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX; In tetrahydrofuran; at -78 ℃; for 7h; Molecular sieve;

With acetic acid; In tetrahydrofuran; methanol; at -78 ℃; for 2h; enantioselective reaction;
DOI:10.1002/adsc.201000843

Reference yield:

: 131323-06-3
α,α-difluoro-4-methylbenzeneacetic acid ethyl ester

: 1292820-68-8
C₂₁H₂₁F₂NO₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / diethyl ether / 12 h / -78 °C

1.2: -78 - 0 °C

2.1: toluene / Reflux

3.1: ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX / tetrahydrofuran / 7 h / -78 °C / Molecular sieve

3.2: 2 h / -78 °C

With lithium aluminium tetrahydride; ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX; In tetrahydrofuran; diethyl ether; toluene; 3.1: Mannich type reaction;
DOI:10.1002/adsc.201000843

Reference yield:

: C₁₁H₁₄F₂O₂

: 2627-86-3
(S)-1-phenyl-ethylamine

: 1292820-68-8
C₂₁H₂₁F₂NO₂

Guidance literature:: Multi-step reaction with 2 steps

1.1: toluene / Reflux

2.1: ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX / tetrahydrofuran / 7 h / -78 °C / Molecular sieve

2.2: 2 h / -78 °C

With ethanol; silver(I) acetate; (aS)-tBu-BinaphPHOX; In tetrahydrofuran; toluene; 2.1: Mannich type reaction;
DOI:10.1002/adsc.201000843