Ethyl 2,2-difluoro-2-(p-tolyl)acetate

Base Information

Chemical Name:Ethyl 2,2-difluoro-2-(p-tolyl)acetate
CAS No.:131323-06-3
Molecular Formula:C11H12F2O2
Molecular Weight:214.212
Hs Code.:2916399090
DSSTox Substance ID:DTXSID90565012
Nikkaji Number:J3.188.297D
Wikidata:Q82449928
Mol file:131323-06-3.mol

Synonyms:131323-06-3;Ethyl 2,2-difluoro-2-(p-tolyl)acetate;ethyl-2,2-difluoro-2-(4-methylphenyl)acetate;Ethyl 2,2-Difluoro-2-(4-methylphenyl)acetate;ethyl difluoro(4-methylphenyl)acetate;DIFLUORO-P-TOLYL-ACETIC ACID ETHYL ESTER;Ethyl Difluoro-(p-tolyl)acetate;SCHEMBL5003336;DTXSID90565012;AC3715;MFCD11007729;AKOS011682063;Ethyl2,2-difluoro-2-(p-tolyl)acetate;FS-6262;SY038865

Suppliers and Price of Ethyl 2,2-difluoro-2-(p-tolyl)acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Ethyl 2,2-difluoro-2-(p-tolyl)acetate
1 g
$ 437.00

Oakwood
EthylDifluoro-(p-tolyl)acetate 90%
25g
$ 2995.00

Crysdot
Ethyl2,2-difluoro-2-(p-tolyl)acetate 95+%
5g
$ 550.00

American Custom Chemicals Corporation
DIFLUORO-PARA-TOLYL ACETIC ACID ETHYL ESTER 95.00%
5MG
$ 504.81

AK Scientific
Ethyl2,2-difluoro-2-(p-tolyl)acetate
1g
$ 323.00

Total 5 raw suppliers

Chemical Property of Ethyl 2,2-difluoro-2-(p-tolyl)acetate

Chemical Property:

Vapor Pressure:0.0159mmHg at 25°C
Boiling Point:255.9°C at 760 mmHg
Flash Point:105.4°C
PSA：26.30000
Density:1.146g/cm³
LogP:2.64990
XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:214.08053595
Heavy Atom Count:15
Complexity:221

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2,2-difluoro-2-(p-tolyl)acetate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(C1=CC=C(C=C1)C)(F)F

Technology Process of Ethyl 2,2-difluoro-2-(p-tolyl)acetate

There total 10 articles about Ethyl 2,2-difluoro-2-(p-tolyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5524-56-1
ethyl 2-p-tolyl-2-oxoacetate

: 131323-06-3
α,α-difluoro-4-methylbenzeneacetic acid ethyl ester

Guidance literature:: With (dimethylamido)sulfur trifluoride; at 0 - 20 ℃;
DOI:10.1021/jm00107a037

Reference yield: 84.0%

: 624-31-7
4-tolyl iodide

: 667-27-6
Ethyl bromodifluoroacetate

: 131323-06-3
α,α-difluoro-4-methylbenzeneacetic acid ethyl ester

Guidance literature:: With copper; In dimethyl sulfoxide; at 60 ℃; for 12h; Inert atmosphere;
DOI:10.1039/c2cc18064b

Reference yield: 54.0%

: 667-27-6
Ethyl bromodifluoroacetate

: 15106-88-4
di(p-tolyl)zinc

: 131323-06-3
α,α-difluoro-4-methylbenzeneacetic acid ethyl ester

Guidance literature:: With N,N,N,N,-tetramethylethylenediamine; cobalt(II) chloride; In tetrahydrofuran; at 25 ℃; for 2h; chemoselective reaction; Inert atmosphere;
DOI:10.1002/chem.202001721