5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

Base Information

Chemical Name:5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde
CAS No.:887499-19-6
Molecular Formula:C₂₀H₂₁NO₃
Molecular Weight:323.392
Hs Code.:

Synonyms:5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

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Chemical Property of 5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

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Technology Process of 5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

There total 1 articles about 5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 864681-96-9
5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester

: 122-51-0
orthoformic acid triethyl ester

: 887499-19-6
5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

Guidance literature:: 5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carboxylic acid tert-butyl ester; With trifluoroacetic acid; at 0 ℃; for 0.166667h;

orthoformic acid triethyl ester; at 0 ℃; for 0.333333h;
DOI:10.1021/jo060041z

Reference yield: 78.0%

: 887499-19-6
5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

: 917-54-4
methyllithium

: 887499-22-1
5-(4,4-dimethyl-2,5-dioxo-1-phenyl-hexyl)-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

Guidance literature:: In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.333333h;
DOI:10.1021/jo060041z

Reference yield:

: 887499-19-6
5-[(4,4-dimethyl-5-oxo-dihydro-furan-2-ylidene)-phenyl-methyl]-3,4-dimethyl-1H-pyrrole-2-carbaldehyde

: 334474-33-8
Z-3,4-dimethyl-5-[1-(4,4,5-trimethyl-3,4-dihydropyrrol-2-ylidene)-phenyl-methyl]-1H-pyrrole-2-carbaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / tetrahydrofuran; diethyl ether / 0.33 h / -78 °C

2: 37 percent / (NH₄)2CO₃; basic alumina / acetonitrile / 8 h / 75 °C

With aluminum oxide; ammonium carbonate; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/jo060041z