3,5-dibenzyloxybenzyl chloride

Base Information

• Chemical Name: 3,5-dibenzyloxybenzyl chloride
• CAS No.: 67093-27-0
• Molecular Formula: C₂₁H₁₉ClO₂
• Molecular Weight: 338.834
• Mol file: 67093-27-0.mol

Synonyms:3,5-dibenzyloxybenzyl chloride

Chemical Property of 3,5-dibenzyloxybenzyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 3,5-dibenzyloxybenzyl chloride

There total 11 articles about 3,5-dibenzyloxybenzyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

3,5-dibenzyloxybenzyl alcohol (24131-31-5) → 3,5-dibenzyloxybenzyl chloride (67093-27-0)

Guidance literature:

With pyridine; thionyl chloride; In dichloromethane; at 0 - 20 ℃; for 3h;

DOI:10.1055/s-0034-1379988

Reference yield: 53.0%

1,3,5-trichloro-2,4,6-triazine (108-77-0) + 3,5-dibenzyloxybenzyl alcohol (24131-31-5) → C24H19Cl2N3O3 (945456-17-7) + 3,5-dibenzyloxybenzyl chloride (67093-27-0)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/ol0708525

Reference yield:

1-carbomethoxy-3,5-dihydroxybenzene (2150-44-9) → 3,5-dibenzyloxybenzyl chloride (67093-27-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: K₂CO₃ / dimethylformamide / 2 h / 20 °C

1.2: 96 percent / dimethylformamide / 14.5 h / 20 °C

2.1: 95 percent / LiAlH₄ / diethyl ether / 4 h / 20 °C

3.1: 93 percent / Et₃N; SOCl₂ / benzene / 2 h / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; triethylamine; In diethyl ether; N,N-dimethyl-formamide; benzene;

DOI:10.1002/anie.200603097

upstream raw materials:

3,5-dibenzyloxybenzyl alcohol

1,3,5-trichloro-2,4,6-triazine

1-carbomethoxy-3,5-dihydroxybenzene

methyl 3,5-bis(benzyloxy)benzoate

Downstream raw materials:

(3',5'-dibenzyloxy)phenylacetonitrile

diethyl <3,5-bis(benzyloxy)benzyl>phosphonate

[3,5-Bis-(3,5-bis-benzyloxy-benzyloxy)-phenyl]-methanol

methyl 3,5-bis[[3,5-bis(phenylmethoxy)phenyl]methoxy] benzoate