N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

Base Information

Chemical Name:N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide
CAS No.:1448441-59-5
Molecular Formula:C₁₆H₁₂BrClFN₃O₃S
Molecular Weight:460.711
Hs Code.:

Synonyms:N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

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Chemical Property of N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

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Technology Process of N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

There total 12 articles about N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.4%

: 1448441-89-1
5-(4-bromo-2-chlorophenyl)-7-(cyclopropylsulfonyl)-4-fluoro-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

: 1448441-59-5
N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

Guidance literature:: With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃; for 1h;

Reference yield: 63.4%

: 1448441-89-1
5-(4-bromo-2-chlorophenyl)-7-(cyclopropylsulfonyl)-4-fluoro-5H-imidazo[4',5':4,5]benzo[1,2-d]oxazol-6(7H)-one

: 10519-96-7
potassium trimethylsilonate

: 1448441-59-5
N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

Guidance literature:: In tetrahydrofuran;

Reference yield:

: 2822-41-5
2,3,4-trifluorophenol

: 1448441-59-5
N-(4-fluoro-5-((4-bromo-2-chlorophenyl)amino)benzo[d]oxazol-6-yl)cyclopropanesulfonamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: sodium carbonate / acetone / 24 h / 50 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -78 °C / Inert atmosphere

2.2: 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / -78 - 20 °C / Inert atmosphere

4.1: potassium hydrogencarbonate / N,N-dimethyl-formamide / 5 h / 20 °C

5.1: sodium azide / N,N-dimethyl-formamide / 3 h / 90 °C

6.1: palladium 10% on activated carbon; hydrogen / methanol / 3 h / 20 °C / Inert atmosphere

7.1: toluene-4-sulfonic acid / 1 h

8.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 4 h / 20 °C

9.1: diphenyl phosphoryl azide; triethylamine / tert-butyl alcohol / 3 h / Reflux

10.1: triethylamine; dmap / dichloromethane / 1 h / 0 - 20 °C

11.1: potassium trimethylsilonate / tetrahydrofuran / 1 h / 20 °C

With dmap; N-Bromosuccinimide; n-butyllithium; sodium azide; diphenyl phosphoryl azide; palladium 10% on activated carbon; potassium trimethylsilonate; hydrogen; sodium carbonate; potassium hydrogencarbonate; toluene-4-sulfonic acid; triethylamine; diisopropylamine; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; acetone; tert-butyl alcohol;