3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole

Base Information

• Chemical Name: 3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole
• CAS No.: 83060-69-9
• Molecular Formula: C₃₂H₃₃N₃O₄S
• Molecular Weight: 555.698

Synonyms:3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole

Chemical Property of 3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole

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Technology Process of 3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole

There total 1 articles about 3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile (77691-00-0) → 3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole (83060-69-9)

Guidance literature:

With hydrogen sulfide; triethylamine; In pyridine; at 60 ℃; for 24h;

DOI:10.1021/jo00154a005

Reference yield: 98.0%

3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole (83060-69-9) → 3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile (77691-00-0)

Guidance literature:

With di(n-butyl)tin oxide; In methanol; for 0.5h; Heating;

DOI:10.1021/jo00144a043

Reference yield: 82.0%

3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole (83060-69-9) + orthoformic acid triethyl ester (122-51-0) → 7-(2',3'-O-Isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-4-thioxo-3H,5H-pyrrolo<3,2-d>pyrimidine (84649-19-4)

Guidance literature:

at 90 ℃; for 5h;

DOI:10.1021/jo00154a005

upstream raw materials:

3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

Downstream raw materials:

3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

7-(2',3'-O-Isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-4-thioxo-3H,5H-pyrrolo<3,2-d>pyrimidine

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