3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

Base Information

Chemical Name:3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile
CAS No.:77691-00-0
Molecular Formula:C₃₂H₃₁N₃O₄
Molecular Weight:521.616
Hs Code.:

Synonyms:3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

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Chemical Property of 3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

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MSDS Files:: SDS file from LookChem

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Technology Process of 3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

There total 5 articles about 3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 83060-69-9
3-amino-4-(2',3'-di-O-isopropylidene-5'-O-trityl-β-D-ribofuranosyl)-2-thiocarboxamido-1H-pyrrole

: 77691-00-0
3-Amino-4-((3aS,4S,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

Guidance literature:: With di(n-butyl)tin oxide; In methanol; for 0.5h; Heating;
DOI:10.1021/jo00144a043

Reference yield:

: 77690-99-4,77691-04-4
3-Amino-2-cyano-4-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-pyrrole-1-carboxylic acid ethyl ester

: 77691-00-0,77691-01-1
3-Amino-4-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

Guidance literature:: With sodium carbonate; In methanol; at 25 ℃; for 0.833333h;
DOI:10.1016/0040-4039(81)80031-7

Reference yield:

: 83348-75-8
2-Formyl-2-(2,3-O-isopropyliden-5-O-trityl-D-ribofuranosyl)acetonitril

: 77691-00-0,77691-01-1
3-Amino-4-((3aS,6R,6aR)-2,2-dimethyl-6-trityloxymethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl)-1H-pyrrole-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: sodium acetate / H₂O; methanol / 20 h / 25 °C

2: 1.) 1,5-diazabicyclo<4,3,0>nonene-5 2.) 1,5-diazabicyclo<4,3,0>nonene-5 / 1.) methylene chloride, 0 deg C, 1 h 2.) 25 deg C, 20 h

3: sodium carbonate / methanol / 0.83 h / 25 °C

With DBN; sodium acetate; sodium carbonate; In methanol; water;
DOI:10.1016/0040-4039(81)80031-7