methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Base Information

Chemical Name:methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate
CAS No.:1005196-65-5
Molecular Formula:C₁₈H₁₉N₅O₄
Molecular Weight:369.38
Hs Code.:

Synonyms:methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

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Chemical Property of methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

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Technology Process of methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

There total 10 articles about methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-methoxy-3-amino-4-methylbenzamide hydrochloride

: 310442-40-1
methyl 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

: 1005196-65-5
methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm7009414

Reference yield:

: 623-43-8,4358-59-2,18707-60-3,130981-57-6
methyl crotonate

: 1005196-65-5
methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydride / mineral oil; diethyl ether; dimethyl sulfoxide / 1 h / 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 48 h / -40 - 20 °C / Inert atmosphere

3.1: sodium methylate / 1 h / 0 - 20 °C / Inert atmosphere

4.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / Inert atmosphere; Green chemistry

4.2: 0.17 h / Inert atmosphere; Green chemistry

5.1: 160 °C

6.1: trichlorophosphate / 115 °C

7.1: N,N-dimethyl-formamide / 20 °C

With aluminum (III) chloride; sodium methylate; sodium hydride; trichlorophosphate; In diethyl ether; dimethyl sulfoxide; 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.07.017

Reference yield:

: 40318-15-8
methyl 4-methyl-1H-pyrrole-3-carboxylate

: 1005196-65-5
methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 48 h / -40 - 20 °C / Inert atmosphere

2.1: sodium methylate / 1 h / 0 - 20 °C / Inert atmosphere

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 1 h / Inert atmosphere; Green chemistry

3.2: 0.17 h / Inert atmosphere; Green chemistry

4.1: 160 °C

5.1: trichlorophosphate / 115 °C

6.1: N,N-dimethyl-formamide / 20 °C

With aluminum (III) chloride; sodium methylate; sodium hydride; trichlorophosphate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1016/j.bmcl.2014.07.017