40318-15-8

Basic information

• Product Name: 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester
• Synonyms: 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester;METHYL 4-METHYL-1H-PYRROLE-3-CARBOXYLATE
• CAS NO: 40318-15-8
• Molecular Formula: C₇H₉NO₂
• Molecular Weight: 139.15
• Product Categories: API intermediates
• Mol File: 40318-15-8.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester(40318-15-8)
• EPA Substance Registry System: 4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester(40318-15-8)

Safety Data

• Hazardous Substances Data: 40318-15-8(Hazardous Substances Data)

Usage

General Description

4-Methyl-1H-pyrrole-3-carboxylic acid methyl ester is a chemical compound that belongs to the class of organic compounds known as pyrroles. Pyrroles are compounds containing a five-membered aromatic ring with four carbon atoms and one nitrogen atom. This particular compound carries a methyl ester functional group and an additional methyl group on the pyrrole ring. Its formula is C7H9NO2 and it presents as a solid substance under standard conditions. Depending upon its specific use, proper handling and safety precautions should be exercised due to potential toxicity. However, specific information on its toxicity, reactions, and uses is not widely available and may require further individual research.

Upstream product

• 623-43-8 methyl crotonate 
• 38622-91-2 [(p-methylphenyl)sulfonylmethyl]isonitrile 
• 4458-69-9 diethyl 5-bromo-3-methylpyrrole-2,4-dicarboxylate 
• 100129-92-8 diethyl 5-chloro-3-methylpyrrole-2,4-dicarboxylate 
• 90561-96-9 5-bromo-3-methyl-pyrrole-2,4-dicarboxylic acid 4-ethyl ester 
• 90346-74-0 5-chloro-3-methyl-pyrrole-2,4-dicarboxylic acid-4-ethyl ester 
• 90610-58-5 4-ethoxycarbonyl-3-methylpyrrole-2-carboxylic acid 
• 2199-49-7 ethyl 4-methylpyrrole-3-carboxylate 
• 623-43-8 crotonic acid methyl ester 
• 186581-53-3 diazomethane 
• 64276-66-0 4-methyl-1H-pyrrole-3-carboxylic acid 

Downstream Products

• 310431-26-6 dimethyl 1-amino-3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 310442-32-1 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310442-33-2 4-[(3-Hydroxy-4-methylphenyl)amino]-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 3780-42-5 dimethyl 3-methyl-1H-pyrrole-2,4-dicarboxylate 
• 310431-29-9 5-methyl-4-oxo-3,4-dihydro-pyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid methyl ester 
• 310442-40-1 methyl 4-chloro-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-65-5 methyl 4-(2-methyl-5-(methoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-67-7 methyl 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylate 
• 1005196-62-2 4-((5-(methoxycarbamoyl)-2-methylphenyl)amino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 1621384-50-6 4-(2-methyl-5-(ethoxycarbamoyl)phenylamino)-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxylic acid 
• 500576-64-7 methyl 5-formyl-4-methyl-1H-pyrrole-3-carboxylate 
• 64276-66-0 4-methyl-1H-pyrrole-3-carboxylic acid 

Relevant articles and documents

Metal-Free Directed C?H Borylation of Pyrroles

Robust strategies to enable the rapid construction of complex organoboronates in selective, practical, low-cost, and environmentally friendly modes remain conspicuously underdeveloped. Here, we develop a general strategy for the site-selective C?H borylation of pyrroles by using only BBr3 directed by pivaloyl groups, avoiding the use of any metal. The site-selectivity is generally dominated by chelation and electronic effects, thus forming diverse C2-borylated pyrroles against the steric effect. The formed products can readily engage in downstream transformations, enabling a step-economic process to access drugs such as Lipitor. DFT calculations (wB97X-D) demonstrate the preferred positional selectivity of this reaction.

Pd(II)-Catalyzed [4 + 2] Heterocyclization Sequence for Polyheterocycle Generation

A new Pd(II)-catalyzed cascade sequence for the formation of polyheterocycles, from simple starting materials, is reported. The sequence is applicable to both indole and pyrrole substrates, and a range of substituents are tolerated. The reaction is thought to proceed by a Pd(II)-catalyzed C-H activated Heck reaction followed by a second Pd(II)-catalyzed aza-Wacker reaction with two Cu(II)-mediated Pd(0) turnovers per sequence. The sequence can be considered a formal [4 + 2] heterocyclization.

Beneficial Effects of Electrochemistry in Cross-Coupling Reactions: Electroreductive Synthesis of 4-Aryl- or 4-Heteroaryl-6-pyrrolylpyrimidines

The rarely described 4-(hetero)aryl-6-pyrrolylpyrimidines are prepared by electroreductive nickel-catalysed cross-coupling reactions between aryl halides and chloropyrimidines. Inherent predictable issues of such metal-catalysed reactions that involve or