7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

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Chemical Name:7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin
CAS No.:98891-40-8
Molecular Formula:C₂₉H₂₉N₃O₆S
Molecular Weight:547.632
Hs Code.:

Synonyms:7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

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Chemical Property of 7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

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Technology Process of 7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

There total 1 articles about 7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 29877-76-7
4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidine

: 98891-40-8
7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

Guidance literature:: With sodium hydroxide; phenyltrimethylammonium chloride; sodium methylate; Yield given. Multistep reaction; 1) CH₂Cl₂, 30 min, 2) CH₃OH, 12 h, r.t.;

Reference yield: 95.0%

: 110-91-8,99108-56-2
morpholine

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 98891-40-8
7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

: 197845-32-2
7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-5-(1-morpholinomethyl)-7H-pyrrolo[2,3-d]pyrimidine

Guidance literature:: With acetic acid; at 60 ℃;
DOI:10.1055/s-1997-1305

Reference yield:

: 98891-40-8
7-[2'-Desoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-4-methoxy-2-methylthio-7H-pyrrolo[2,3-d]pyrimidin

: 197845-33-3
7-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-2-methylthio-5-(1-morpholinomethyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidine-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / aq. HOAc / 60 °C

2: 90 percent / NaI, ClSiMe₃ / acetonitrile / 0.75 h / Ambient temperature

With chloro-trimethyl-silane; acetic acid; sodium iodide; In acetonitrile;
DOI:10.1055/s-1997-1305