29877-76-7 Usage
Uses
Used in Pharmaceutical Industry:
4-METHOXY-2-METHYLSULFANYL-7H-PYRROLO[2,3-D]PYRIMIDINE is used as a potential kinase enzyme inhibitor for its role in the treatment of certain cancers. Its ability to inhibit specific kinase enzymes may help in controlling the growth and progression of cancer cells.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 4-METHOXY-2-METHYLSULFANYL-7H-PYRROLO[2,3-D]PYRIMIDINE serves as a promising candidate for the development of new drugs. Its unique structure and properties make it a valuable compound for further research and exploration in drug discovery processes.
Used in Cancer Research:
4-METHOXY-2-METHYLSULFANYL-7H-PYRROLO[2,3-D]PYRIMIDINE is used as a subject of investigation in cancer research. Its potential as a kinase enzyme inhibitor makes it a valuable tool for understanding the mechanisms of cancer development and identifying new therapeutic targets.
Used in Drug Development:
As a compound with potential applications in the pharmaceutical industry, 4-METHOXY-2-METHYLSULFANYL-7H-PYRROLO[2,3-D]PYRIMIDINE is used in the process of drug development. Its unique properties and potential as a kinase enzyme inhibitor make it a promising candidate for the creation of new and effective cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 29877-76-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,9,8,7 and 7 respectively; the second part has 2 digits, 7 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 29877-76:
(7*2)+(6*9)+(5*8)+(4*7)+(3*7)+(2*7)+(1*6)=177
177 % 10 = 7
So 29877-76-7 is a valid CAS Registry Number.
InChI:InChI=1/C8H9N3OS/c1-12-7-5-3-4-9-6(5)10-8(11-7)13-2/h3-4H,1-2H3,(H,9,10,11)
29877-76-7Relevant academic research and scientific papers
Some pyrrolopyrimidine chemistry directed to the synthesis of tricyclic purine analogues
Williams, David M.,Brown, Daniel M.
, p. 1225 - 1232 (2007/10/02)
Chemistry directed to the synthesis of the tricyclic ring system 3, a purine analogue with degenerate hydrogen-bonding potential, has been investigated and has resulted in the synthesis of several novel pyrrolopyrimidine derivatives as potential precursors.The known analogue 2-amino-7H-pyrrolopyrimidin-4-one (7-deazaguanine) is converted by the Vilsmeier reagent into 4-chloro-2-dimethylaminomethyleneamino-6-formyl-7H-pyrrolopyrimidine 10.Formylation at the α-position of the pyrrole ring was determined by the comparison of 13C NMR data of the corresponding alcohol and the unsabstituted derivative and is in agreement with the regiospecificity reported for the Mannich reaction of this compound.In contrast, base-catalysed hydroxymethylation of 4-chloro-2-methylsulfanyl-7H-pyrrolopyrimidine with formaldehyde in aqueous THF occurs at the desired β-position to afford the 5-hydroxymethyl product 17. 7-Methylation of the t-BuMe2Si-protected alcohol 17 led to several potential precursors of the desired tricyclic structure.The 5-phthalimidooxymethyl derivatives of either 2-methylsulfanyl- or 4-chloro-2-methylsulfonyl-7H-pyrrolopyrimidine with ammonia gave the aminooxymethyl derivatives but these subsequently failed to cyclise.Several approaches to cyclise 4-hydroxyamino-5-hydroxymethyl-7-methyl-2-methylsulfonyl-7H-pyrrolopyrimidine 27 afforded the corresponding 4-amino compound as the major component.Both the experimental and modelling results show that considerable strain is associated with the formation of 3.
