N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide

Base Information

Chemical Name:N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide
CAS No.:7574-50-7
Molecular Formula:C17H12 F6 N2 O2
Molecular Weight:390.2798
Hs Code.:
DSSTox Substance ID:DTXSID10363350
Wikidata:Q82147012
Mol file:7574-50-7.mol

Synonyms:N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide;7574-50-7;8G-904;Bionet1_002035;N~1~,N~3~-bis[4-(trifluoromethyl)phenyl]malonamide;SCHEMBL5142584;HMS574B17;DTXSID10363350;AKOS005103116

Suppliers and Price of N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
N1,N3-BIS[4-(TRIFLUOROMETHYL)PHENYL]MALONAMIDE 95.00%
5MG
$ 500.53

Total 5 raw suppliers

Chemical Property of N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide

Chemical Property:

Boiling Point:536°Cat760mmHg
Flash Point:278°C
PSA：58.20000
Density:1.461g/cm³
LogP:4.83750
XLogP3:5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:4
Exact Mass:390.08029660
Heavy Atom Count:27
Complexity:473

Purity/Quality:

95% ^*data from raw suppliers

N1,N3-BIS[4-(TRIFLUOROMETHYL)PHENYL]MALONAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C(F)(F)F)NC(=O)CC(=O)NC2=CC=C(C=C2)C(F)(F)F

Technology Process of N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide

There total 2 articles about N,N'-bis[4-(trifluoromethyl)phenyl]propanediamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 455-14-1
4-trifluoromethylphenylamine

: 1663-67-8
malonoyl dichloride

: 7574-50-7
N,N'-bis[(4-trifluoromethyl)phenyl]malonodiamide

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm970039n

Reference yield: 65.0%

: 7574-50-7
N,N'-bis[(4-trifluoromethyl)phenyl]malonodiamide

Guidance literature:

Reference yield:

: 7574-50-7
N,N'-bis[(4-trifluoromethyl)phenyl]malonodiamide

: 852203-19-1
3-bromo-4-(5-chloro-2-methoxyphenyl)-6-(trifluoromethyl)quinolin-2(1H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: 65 percent / phosphorus pentoxide; methanesulfonic acid / 0.33 h / 120 °C / microwave irradiation

2: 81 percent / phosphorus oxychloride / dioxane / 0.25 h / 120 °C / microwave irradiation

3: 90 percent / methanesulfonic acid / ethanol / 0.33 h / 150 °C / microwave irradiation

4: 91 percent / triethylamine; PPh₃ / Pd(OAc)2 / 1,2-dimethoxy-ethane; H₂O / 0.5 h / 150 °C / microwave irradiation

5: 87 percent / N-bromosuccinimide / acetonitrile / 0.83 h / 150 °C / microwave irradiation

With phosphorus pentaoxide; N-Bromosuccinimide; methanesulfonic acid; triethylamine; triphenylphosphine; trichlorophosphate; palladium diacetate; In 1,4-dioxane; 1,2-dimethoxyethane; ethanol; water; acetonitrile; 4: Suzuki cross-coupling;
DOI:10.1021/jo0502549