(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

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Chemical Name:(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol
CAS No.:192047-51-1
Molecular Formula:C₂₇H₄₈O₅S₂Si
Molecular Weight:544.893
Hs Code.:

Synonyms:(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

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Chemical Property of (R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

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Technology Process of (R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

There total 1 articles about (R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 95452-06-5
tert-butyl(1,3-dithian-2-yl)dimethylsilane

: 14618-80-5
(R)-benzyl glycidol

: (R)-2-(1-Methoxy-1-methyl-ethoxymethyl)-oxirane

: 192047-51-1
(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

Guidance literature:: tert-butyl(1,3-dithian-2-yl)dimethylsilane; With tert.-butyl lithium; In diethyl ether; pentane; at -78 - -45 ℃; for 1h;

(R)-benzyl glycidol; In diethyl ether; pentane; at -78 - -25 ℃; for 1h;

(R)-2-(1-Methoxy-1-methyl-ethoxymethyl)-oxirane; With N,N,N,N,N,N-hexamethylphosphoric triamide; In diethyl ether; pentane; at -78 - 20 ℃; for 2h;
DOI:10.1021/ja0376238

Reference yield: 69.0%

: 192047-51-1
(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

: (R)-3-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propane-1,2-diol

Guidance literature:: With pyridinium p-toluenesulfonate; In methanol; at 0 ℃; for 0.333333h;
DOI:10.1021/ja0376238

Reference yield:

: 192047-51-1
(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

: [(R)-1-Benzyloxymethyl-2-(2-(R)-1-oxiranylmethyl-[1,3]dithian-2-yl)-ethoxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / PPTS / methanol / 0.33 h / 0 °C

2: 81 percent / tosyl imidazole; NaH / tetrahydrofuran / 1 h / 0 - 20 °C

With pyridinium p-toluenesulfonate; sodium hydride; p-toluenesulfonyl imidazole; In tetrahydrofuran; methanol;
DOI:10.1021/ja0376238