2-(TERT-BUTYLDIMETHYLSILYL)-1,3-DITHIANE

Base Information

• Chemical Name: 2-(TERT-BUTYLDIMETHYLSILYL)-1,3-DITHIANE
• CAS No.: 95452-06-5
• Molecular Formula: C10H22 S2 Si
• Molecular Weight: 234.502
• Hs Code.: 2934999090
• Mol file: 95452-06-5.mol

Synonyms:Silane,(1,1-dimethylethyl)-1,3-dithian-2-yldimethyl- (9CI);2-(tert-Butyldimethylsilyl)-1,3-dithiane

Chemical Property of 2-(TERT-BUTYLDIMETHYLSILYL)-1,3-DITHIANE

Chemical Property:

• Vapor Pressure: 0.00483mmHg at 25°C
• Refractive Index: n20/D 1.531(lit.)
• Boiling Point: 124 °C5 mm Hg(lit.)
• Flash Point: 221 °F
• PSA: 50.60000
• Density: 1.01 g/mL at 25 °C(lit.)
• LogP: 4.65020
• Solubility.: insoluble in H2O; soluble in organic solvents.

Purity/Quality:

98%min ^*data from raw suppliers

2-(tert-Butyldimethylsilyl)-1,3-dithiane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Physical properties: bp 115°C/0.03mmHg, 124°C/5mmHg, d 1.010.
• Uses: 2-t-Butyldimethylsilyl-1,3-dithiane can be as an anion undergoes alkylation with electrophiles subsequently providing a general synthesis to acyl silanes;anion undergoes.

Technology Process of 2-(TERT-BUTYLDIMETHYLSILYL)-1,3-DITHIANE

There total 2 articles about 2-(TERT-BUTYLDIMETHYLSILYL)-1,3-DITHIANE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

1,3 dithiane (505-23-7) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl(1,3-dithian-2-yl)dimethylsilane (95452-06-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1002/hlca.19840670711

Reference yield:

2-lithio-1,3-dithiane (36049-90-8) + tert-butyldimethylsilyl chloride (18162-48-6) → tert-butyl(1,3-dithian-2-yl)dimethylsilane (95452-06-5)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 2h;

DOI:10.1021/ja970371o

Reference yield: 96.0%

(S)-benzyl glycidyl ether (2930-05-4,14618-80-5,89616-40-0,16495-13-9) + tert-butyl(1,3-dithian-2-yl)dimethylsilane (95452-06-5) → C30H46O4S2Si (941578-65-0)

Guidance literature:

tert-butyl(1,3-dithian-2-yl)dimethylsilane; With n-butyllithium; In tetrahydrofuran; hexane; at 20 ℃; for 0.166667h;

(S)-benzyl glycidyl ether; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; at -78 - 20 ℃; for 1.5h; Further stages.;

DOI:10.1021/jo070346t

upstream raw materials:

1,3 dithiane

tert-butyldimethylsilyl chloride

2-lithio-1,3-dithiane

Downstream raw materials:

2-<3'-(2,2-dimethyl-6-methylidenecyclohexyl)propyl>-2-<(tert-butyl)dimethylsilyl>-1,3-dithiane

formyl-tert-butyldimethylsilane 2,4-dinitrophenylhydrazone

(R)-1-{2-[(R)-3-Benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-3-(1-methoxy-1-methyl-ethoxy)-propan-2-ol

(2R)-1-benzyloxy-3-{2-[(2R)-3-benzyloxy-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-[1,3]dithian-2-yl}-propan-2-ol