N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

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Chemical Name:N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide
CAS No.:861959-92-4
Molecular Formula:C₂₃H₃₆N₄O₆S₂
Molecular Weight:528.694
Hs Code.:

Synonyms:N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

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Chemical Property of N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

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Technology Process of N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

There total 1 articles about N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 219931-70-1
(2S)-N-{5-methoxy-4-[3-(carboxy)propyloxy]-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl dithioacetal

: 861959-92-4
N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide*HCl; 1-hydroxybenzotriazole / dimethylformamide / 6 h / 20 °C

2: 72 percent / BF₃*OEt₂; EtSH / CH₂Cl₂ / 20 °C

With boron trifluoride diethyl etherate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; ethanethiol; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2005.02.005

Reference yield: 77.0%

: 861959-92-4
N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

: 861960-09-0
[(4-{[4-({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-imidazole-2-carbonyl}amino)-1-methyl-1H-imidazole-2-carbonyl]amino}-1-methyl-1H-imidazole-2-carbonyl)amino]acetic acid

: 861960-15-8
C₆₁H₈₂N₁₆O₁₆S₄

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2005.02.005

Reference yield: 76.0%

: 861959-92-4
N-(2-aminoethyl)-4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyramide

: 861960-05-6
{[4-({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}acetic acid

: 861960-11-4
C₅₈H₇₉N₁₁O₁₅S₄

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2005.02.005