219931-70-1

Upstream product

• 121-33-5 vanillin 
• 105089-88-1 (2S)-2-[di(ethylsulfanyl)methyl]tetrahydro-1H-pyrrole 
• 219931-68-7 5-methoxy-4-[3-(carbethoxy)propyloxy]-2-nitrobenzoic acid 
• 219931-67-6 ethyl 4-(4-formyl-2-methoxy-5-nitrophenoxy)butanoate 
• 127810-77-9 (2S)-N-[4-benzyloxy-5-methoxy-2-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl dithioacetal 
• 349536-25-0 (2S)-N-[5'-methoxy-4'-[(3''-methoxycarbonylpropyl)oxy]-2'-nitrobenzoyl]pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 219931-69-8 (2S)-N-[5-methoxy-4-[3-(carboethoxy)propyloxy]-2-nitrobenzoyl]pyrrolidine-2-carboxaldehydediethylthioacetal 
• 140647-02-5 (2S)-N-(4-hydroxy-5-methoxy-2-nitrobenzoyl)pyrrolidine-2-carboxaldehyde diethyl thioacetal 

Downstream Products

• 219931-73-4 C₄₄H₆₀N₁₀O₉S₂ 
• 463326-48-9 4-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyrylamino)-1-methyl-1H-imidazole-2-carboxylic acid (3-dimethylamino-propyl)-amide 
• 463326-54-7 4-{[4-(4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyrylamino)-1-methyl-1H-pyrrole-2-carbonyl]-amino}-1-methyl-1H-imidazole-2-carboxylic acid (3-dimethylamino-propyl)-amide 
• 463326-49-0 C₃₆H₅₂N₁₀O₈S₂ 
• 463326-50-3 C₄₁H₅₇N₁₃O₉S₂ 
• 463326-55-8 C₄₃H₅₉N₁₁O₉S₂ 
• 625457-62-7 4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-N-chrysen-6-yl-butyramide 
• 678154-62-6 (2S)-N-{4-[N-(1''-pyrenyl)-propane-3'-carboxamide]-oxy-5-methoxy-2-nitrobenzoyl}pyrrolidine-2-carboxaldehyde diethyl thioacetal 
• 642479-06-9 N-(8-benzyloxy-7-methoxy-5,11-dioxo-2,3,5,10,11,11a-hexahydro-1H-benzo[e]pyrrolo[1,2-a][1,4]diazepin-2-yl)-4-{4-[2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyramide 
• 642478-91-9 N-[(3S,5S)-1-(4-Benzyloxy-5-methoxy-2-nitro-benzoyl)-5-(bis-ethylsulfanyl-methyl)-pyrrolidin-3-yl]-4-{4-[(S)-2-(bis-ethylsulfanyl-methyl)-pyrrolidine-1-carbonyl]-2-methoxy-5-nitro-phenoxy}-butyramide 
• 861959-93-5 4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 861959-98-0 ({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)acetic acid methyl ester 
• 861959-99-1 {[4-({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}acetic acid methyl ester 
• 861960-00-1 [(4-{[4-({4-[4-(4-{(2S)-2-[bis(ethylsulfanyl)methyl]pyrrolidine-1-carbonyl}-2-methoxy-5-nitrophenoxy)butyrylamino]-1-methyl-1H-pyrrole-2-carbonyl}amino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]acetic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and antitumour activity of pyrene-linked pyrrolo [2,1-c][1,4]benzodiazepine hybrids

Pyrene-linked pyrrolobenzodiazepine hybrids have been synthesized that exhibit potential anticancer activity in a number of human tumour cell lines. These hybrids also exhibit much enhanced DNA-binding ability in comparison to the parent pyrrolobenzodiazepine ring system (DC-81).

Synthesis and DNA-binding affinity of A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers

The synthesis of new A-C8/C-C2 alkoxyamido-linked pyrrolo[2,1-c][1,4]- benzodiazepine dimers have been described in this report. These dimers exhibit significant DNA-binding ability with moderate anticancer activity.

Design and synthesis of novel chrysene-linked pyrrolo[2,1-c][1,4]-benzodiazepine hybrids as potential DNA-binding agents

Chrysene-linked pyrrolobenzodiazepine hybrids have been prepared that posses cytotoxicity in some cancer cell lines. They also exhibit promising DNA-binding affinity and this is supported by molecular modeling studies.

Design and synthesis of novel pyrrolo[2,1-c][1,4]benzodiazepine - Imidazole containing polyamide conjugates

A series of novel pyrrolo[2,1-c][1,4]benzodiazepine (PBD) - polyamide conjugates (1-5) containing imidazole units was synthesized as DNA minor groove bining agents.