3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
CAS No.:1570495-56-5
Molecular Formula:C₂₄H₂₄F₃N₇O₂
Molecular Weight:499.495
Hs Code.:

Synonyms:3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Chemical Property of 3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Technology Process of 3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

There total 3 articles about 3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1570495-66-7
N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

: 330-12-1
4-trifluoromethoxybenzoic acid

: 1570495-56-5
3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: 4-trifluoromethoxybenzoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 4h;

N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide; In dichloromethane; at 45 ℃; for 6h;

In N,N-dimethyl-formamide; at 135 ℃; for 2h;

Reference yield:

: 1570495-60-1
1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide

: 1570495-56-5
3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C

2.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 100 °C / Inert atmosphere

3.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 80 °C

4.1: 1,1'-carbonyldiimidazole / dichloromethane / 4 h / 20 °C

4.2: 6 h / 45 °C

4.3: 2 h / 135 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; trifluoroacetic anhydride; XPhos; In ethanol; dichloromethane; toluene;

Reference yield:

: 1570495-62-3
1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carbonitrile

: 1570495-56-5
3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 100 °C / Inert atmosphere

2.1: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 80 °C

3.1: 1,1'-carbonyldiimidazole / dichloromethane / 4 h / 20 °C

3.2: 6 h / 45 °C

3.3: 2 h / 135 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; 1,1'-carbonyldiimidazole; XPhos; In ethanol; dichloromethane; toluene;