N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

Base Information

Chemical Name:N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide
CAS No.:1570495-66-7
Molecular Formula:C₁₆H₂₃N₇O
Molecular Weight:329.405
Hs Code.:

Synonyms:N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

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Technology Process of N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

There total 2 articles about N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1570495-60-1
1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carboxamide

: 1570495-66-7
N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic anhydride; triethylamine / dichloromethane / 0 - 20 °C

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 100 °C / Inert atmosphere

3: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; caesium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic anhydride; XPhos; In ethanol; dichloromethane; toluene;

Reference yield:

: 1570495-62-3
1-(3-bromobenzyl)-5-methyl-1H-1,2,4-triazole-3-carbonitrile

: 1570495-66-7
N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / toluene / 100 °C / Inert atmosphere

2: hydroxylamine hydrochloride; N-ethyl-N,N-diisopropylamine / ethanol / 2 h / 80 °C

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; hydroxylamine hydrochloride; caesium carbonate; N-ethyl-N,N-diisopropylamine; XPhos; In ethanol; toluene;

Reference yield:

: 1570495-66-7
N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide

: 330-12-1
4-trifluoromethoxybenzoic acid

: 1570495-56-5
3-(5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazol-3-yl)-5-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: 4-trifluoromethoxybenzoic acid; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 4h;

N-hydroxy-5-methyl-1-(3-(4-methylpiperazin-1-yl)benzyl)-1H-1,2,4-triazole-3-carboximidamide; In dichloromethane; at 45 ℃; for 6h;

In N,N-dimethyl-formamide; at 135 ℃; for 2h;