N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

Base Information

Chemical Name:N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine
CAS No.:1073230-18-8
Molecular Formula:C₁₉H₁₄F₃N₃O₅
Molecular Weight:421.332
Hs Code.:

Synonyms:N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

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Chemical Property of N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

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Technology Process of N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

There total 4 articles about N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073230-21-3
tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

: 1073230-18-8
N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 12h;

Reference yield:

: 1073230-19-9
1-[4-(trifluoromethyl)benzyl]-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

: 1073230-18-8
N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.83 h / 0 - 20 °C

1.2: 3 h / 60 °C

2.1: ethanol / 3 h / 130 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With sodium hydride; trifluoroacetic acid; In ethanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1073230-20-2
ethyl-4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridine-3-carboxylate

: 1073230-18-8
N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycine

Guidance literature:: Multi-step reaction with 2 steps

1: ethanol / 3 h / 130 °C / Microwave irradiation

2: trifluoroacetic acid / dichloromethane / 12 h / 20 °C

With trifluoroacetic acid; In ethanol; dichloromethane;