tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

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Chemical Name:tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate
CAS No.:1073230-21-3
Molecular Formula:C₂₃H₂₂F₃N₃O₅
Molecular Weight:477.44
Hs Code.:

Synonyms:tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

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Chemical Property of tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

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Technology Process of tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

There total 3 articles about tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1073230-20-2
ethyl-4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridine-3-carboxylate

: 6456-74-2
Glycine tert-butyl ester

: 1073230-21-3
tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

Guidance literature:: In ethanol; at 130 ℃; for 3h; Microwave irradiation;

Reference yield:

: 1073230-19-9
1-[4-(trifluoromethyl)benzyl]-2H-pyrido[2,3-d][1,3]oxazine-2,4(1H)-dione

: 1073230-21-3
tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.83 h / 0 - 20 °C

1.2: 3 h / 60 °C

2.1: ethanol / 3 h / 130 °C / Microwave irradiation

With sodium hydride; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 5860-70-8
2-Aminocarbonylnicotinic acid

: 1073230-21-3
tert-butyl N-({4-hydroxy-2-oxo-1-[4-(trifluoromethyl)benzyl]-1,2-dihydro-1,8-naphthyridin-3-yl}carbonyl)glycinate

Guidance literature:: Multi-step reaction with 4 steps

1.1: lead(IV) acetate / N,N-dimethyl-formamide / 1 h / 0 - 55 °C

2.1: sodium hydride / ISOPROPYLAMIDE / 0.33 h / 20 - 60 °C

2.2: 4 h / 0 - 20 °C

3.1: sodium hydride / N,N-dimethyl-formamide / 0.83 h / 0 - 20 °C

3.2: 3 h / 60 °C

4.1: ethanol / 3 h / 130 °C / Microwave irradiation

With lead(IV) acetate; sodium hydride; In ethanol; ISOPROPYLAMIDE; N,N-dimethyl-formamide;