tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Base Information

• Chemical Name: tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate
• CAS No.: 1227471-74-0
• Molecular Formula: C₂₅H₂₉F₃N₂O₄
• Molecular Weight: 478.511

Synonyms:tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property of tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

Chemical Property:

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Technology Process of tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

There total 1 articles about tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (898157-46-5) + 3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenylboronic acid (1227471-73-9) → tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227471-74-0)

Guidance literature:

With sodium hexamethyldisilazane; nickel(II) iodide; R,S-trans-2-aminocyclohexan-1-ol; In isopropyl alcohol; at 60 ℃; for 6h; Inert atmosphere; Sealed tube;

Reference yield: 100.0%

tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227471-74-0) → (3RS)-3-(3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-1-oxa-8-azaspiro[4.5]decane hydrochloride

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; for 1h;

Reference yield: 89.0%

tert-butyl (3RS)-3-(3-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227471-74-0) → tert-butyl (3R)-3-(3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227471-78-4) + tert-butyl (3S)-3-(3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate (1227471-77-3)

Guidance literature:

With ChiralPak OD-H column; In methanol; carbon dioxide; Resolution of racemate;

upstream raw materials:

tert-butyl 3-bromo-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenylboronic acid

Downstream raw materials:

tert-butyl (3R)-3-(3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

tert-butyl (3S)-3-(3-([5-(trifluoromethyl)pyridin-2-yl]oxy)phenyl)-1-oxa-8-azaspiro[4.5]decane-8-carboxylate

C₂₆H₂₇F₃N₄O₄

C₂₆H₂₅F₃N₄O₃

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