1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Base Information

Chemical Name:1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea
CAS No.:1207357-39-8
Molecular Formula:C₁₉H₂₄N₆O₂
Molecular Weight:368.439
Hs Code.:

Synonyms:1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

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Chemical Property of 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

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Technology Process of 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

There total 3 articles about 1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1207365-96-5
tert-butyl 2-(4-(3-ethylureido)phenyl)-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate

: 1207357-39-8
1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: tert-butyl 2-(4-(3-ethylureido)phenyl)-4-morpholino-5H-pyrrolo[3,4-d]pyrimidine-6(7H)-carboxylate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 2h;

In methanol; dichloromethane; for 1h; pH=> 7;

Reference yield:

: 1207368-80-6
tert-butyl 2-chloro-4-morpholino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1207357-39-8
1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 0.42 h / 120 °C / Microwave irradiation

2.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.2: tetraalkylammonium carbonate polymer-bound resin / 1 h / 20 °C / pH > 7

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; trifluoroacetic acid; In dichloromethane; water; acetonitrile; 1.1: |Suzuki Coupling;
DOI:10.1021/jm301389h

Reference yield:

: 903129-71-5
tert-butyl 2,4-dichloro-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxylate

: 1207357-39-8
1-ethyl-3-(4-(4-morpholino-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-2-yl)phenyl)urea

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 20 °C

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate / water; acetonitrile / 0.42 h / 120 °C / Microwave irradiation

3.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

3.2: tetraalkylammonium carbonate polymer-bound resin / 1 h / 20 °C / pH > 7

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane; water; isopropyl alcohol; acetonitrile; 2.1: |Suzuki Coupling;
DOI:10.1021/jm301389h