2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid

Base Information

• Chemical Name: 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid
• CAS No.: 80353-59-9
• Molecular Formula: C₁₈H₁₆Cl₂O₃
• Molecular Weight: 351.229
• Mol file: 80353-59-9.mol

Synonyms:2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid

Chemical Property of 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid

There total 6 articles about 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(3,4-dichlorophenyl)-4-oxo-2-butenoic acid (22660-10-2) + m-xylene (108-38-3,104809-90-7) → 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid (80353-59-9)

Guidance literature:

With hydrogenchloride; aluminium trichloride; at 20 - 25 ℃; for 15h;

DOI:10.1055/s-1981-29600

Reference yield: 53.0%

4-(3,4-Dichloro-phenyl)-2-(2,4-dimethyl-phenyl)-N-[2-(2,4-dimethyl-phenyl)-2-oxo-ethyl]-4-oxo-butyramide (80353-58-8) → 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid (80353-59-9)

Guidance literature:

With hydrogenchloride; acetic acid; for 4h; Heating;

DOI:10.1055/s-1981-29600

Reference yield:

4-(3,4-dichlorophenyl)-4-oxo-2-butenoic acid (22660-10-2) → 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid (80353-59-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Pyridine, thionyl chloride, 2.) aq. KOH / Benzene; 1.) 0 deg C, 30 min, 2.) 1 h, r.t.

2: 83 percent / Acetic anhydride / 1 h / 100 °C

3: 69 percent / AlCl₃ / 10 h / Ambient temperature

4: 53 percent / Glacial acetic acid, conc. HCl / 4 h / Heating

With pyridine; hydrogenchloride; potassium hydroxide; aluminium trichloride; thionyl chloride; acetic anhydride; acetic acid;

DOI:10.1055/s-1981-29600

upstream raw materials:

4-(3,4-Dichloro-phenyl)-2-(2,4-dimethyl-phenyl)-N-[2-(2,4-dimethyl-phenyl)-2-oxo-ethyl]-4-oxo-butyramide

4-(3,4-dichlorophenyl)-4-oxo-2-butenoic acid

m-xylene

2-<3-(3,4-Dichlorophenyl)-3-oxopropenyl>-5-oxo-4,5-dihydro-1,3-oxazole