22660-10-2

Upstream product

• 298-12-4 Glyoxilic acid 
• 2642-63-9 3',4'-dichloroacetophenone 
• 108-31-6 maleic anhydride 
• 95-50-1 1,2-dichloro-benzene 

Downstream Products

• 56428-23-0 3-(3.4-dichlorobenzoyl)-2'.6'-dimethylacrylanilide 
• 56428-55-8 3-(3.4-dichlorobenzoyl)-2'.6'-dichloroacrylanilide 
• 78860-80-7 4-(3,4-Dichloro-phenyl)-2-(1H-indol-3-yl)-4-oxo-butyric acid 
• 78860-83-0 4-(3,4-Dichloro-phenyl)-2-(1,2-dimethyl-1H-indol-3-yl)-4-oxo-butyric acid 
• 80353-59-9 2-(2,4-Dimethylphenyl)-4-(3,4-dichlorophenyl)-4-oxobutanoic acid 
• 78860-88-5 6-(3,4-Dichlorophenyl)-4-(indol-3-yl)-2,3,4,5-tetrahydropyridazin-3-one 
• 78861-05-9 4-(3,4-Dichloro-phenyl)-2-(1H-indol-3-yl)-4-oxo-butyric acid methyl ester 
• 78860-91-0 6-(3,4-Dichloro-phenyl)-4-(1,2-dimethyl-1H-indol-3-yl)-4,5-dihydro-2H-pyridazin-3-one 
• 78861-08-2 4-(3,4-Dichloro-phenyl)-2-(1,2-dimethyl-1H-indol-3-yl)-4-oxo-butyric acid methyl ester 
• 78860-95-4 6-(3,4-Dichloro-phenyl)-4-(1H-indol-3-yl)-2-phenyl-4,5-dihydro-2H-pyridazin-3-one 
• 78860-97-6 6-(3,4-Dichloro-phenyl)-4-(1,2-dimethyl-1H-indol-3-yl)-2-phenyl-4,5-dihydro-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis of chiral γ-lactones via a RuPHOX-Ru catalyzed asymmetric hydrogenation of aroylacrylic acids

An asymmetric hydrogenation of aroylacrylic acids catalyzed by RuPHOX-Ru catalyst has been developed, affording the corresponding chiral γ-lactones in high yields and with up to 93% ee. The methodology has the advantage of utilizing easily accessible substrates and has therefore expand the scope of the resulting chiral γ-lactones. Furthermore, high catalytic efficiency was achieved in that the reduction of both the C[dbnd]C and C[dbnd]O double bonds was achieved in one step. The current work provides an alternative and convenient pathway for the synthesis of a wide range of chiral γ-lactones.

Utility of β-aroyl acrylic acid in heterocyclic synthesis

β-(4-bromobenzoyl) acrylic acid has been reacted with nitrogen nucleophiles namely ethanolamine and o-aminophenol and yielded the corresponding adduct la,b. On the other hand, ss-(3,4dichlorobenzoyl) acrylic acid has been reacted with carbon nucleophiles

4-phenyl-4-oxo-2-butenoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

PCT No. PCT/EP96/04517 Sec. 371 Date May 4, 1998 Sec. 102(e) Date May 4, 1998 PCT Filed Oct. 16, 1996 PCT Pub. No. WO97/17316 PCT Pub. Date May 15, 19974-Phenyl-4-oxo-butenoic acid derivatives for use in the treatment of the human or animal body by therapy; particularly as kynurenine-3-hydroxylase inhibitors, in the prevention and/or treatment of a neurodegenerative disease wherein the inhibition of such an enzyme is needed. The present invention further comprises a selected class of the above mentioned 4-phenyl-4-oxo-butenoic acid derivatives, their pharmaceutically acceptable salts, a process for their preparation and pharmaceutical compositions containing them.