4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

Base Information

Chemical Name:4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol
CAS No.:1026931-77-0
Molecular Formula:C₁₉H₁₆F₃NOS
Molecular Weight:363.403
Hs Code.:

Synonyms:4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

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Chemical Property of 4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

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Technology Process of 4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

There total 5 articles about 4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 929693-58-3
4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 1026931-77-0
4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

Guidance literature:: With boron tribromide; In dichloromethane; at -20 ℃; for 72h;
DOI:10.1021/jm058056x

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 1026931-77-0
4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

Guidance literature:: Multi-step reaction with 5 steps

1.1: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

2.1: 62.5 percent / PCC / CH₂Cl₂ / 3 h / 20 °C

3.1: NaH / CH₂Cl₂ / 0.5 h / cooling

3.2: 92 percent / CH₂Cl₂ / 0 - 20 °C

4.1: 98 percent / H₂; AcOH / Pd/C / ethanol / 24 h / 60 °C

5.1: 96 percent / BBr₃ / CH₂Cl₂ / 72 h / -20 °C

With lithium aluminium tetrahydride; hydrogen; boron tribromide; sodium hydride; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm058056x

Reference yield:

: 438577-61-8
4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

: 1026931-77-0
4-(2-{4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazol-5-yl}ethyl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / CH₂Cl₂ / 0.5 h / cooling

1.2: 92 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 98 percent / H₂; AcOH / Pd/C / ethanol / 24 h / 60 °C

3.1: 96 percent / BBr₃ / CH₂Cl₂ / 72 h / -20 °C

With hydrogen; boron tribromide; sodium hydride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm058056x