4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

Base Information

Chemical Name:4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole
CAS No.:929693-58-3
Molecular Formula:C₂₀H₁₈F₃NOS
Molecular Weight:377.43
Hs Code.:

Synonyms:4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

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Chemical Property of 4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

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Technology Process of 4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

There total 5 articles about 4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethenyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

: 929693-58-3
4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethanol; at 60 ℃; for 24h;
DOI:10.1021/jm058056x

Reference yield:

: 175277-03-9
4-methyl-2-[4-(trifluoromethyl)phenyl]thiazole-5-carboxylic acid ethyl ester

: 929693-58-3
4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: 80.2 g / LiAlH₄ / tetrahydrofuran / 1.3 h / 20 °C

2.1: 62.5 percent / PCC / CH₂Cl₂ / 3 h / 20 °C

3.1: NaH / CH₂Cl₂ / 0.5 h / cooling

3.2: 92 percent / CH₂Cl₂ / 0 - 20 °C

4.1: 98 percent / H₂; AcOH / Pd/C / ethanol / 24 h / 60 °C

With lithium aluminium tetrahydride; hydrogen; sodium hydride; acetic acid; pyridinium chlorochromate; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm058056x

Reference yield:

: 438577-61-8
4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole-5-carbaldehyde

: 929693-58-3
4-methyl-5-{(E)-2-[4-(methoxy)phenyl]ethyl}-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / CH₂Cl₂ / 0.5 h / cooling

1.2: 92 percent / CH₂Cl₂ / 0 - 20 °C

2.1: 98 percent / H₂; AcOH / Pd/C / ethanol / 24 h / 60 °C

With hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In ethanol; dichloromethane;
DOI:10.1021/jm058056x