{(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester

Base Information

• Chemical Name: {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester
• CAS No.: 854001-46-0
• Molecular Formula: C₃₆H₃₅N₂O₃P
• Molecular Weight: 574.659

Synonyms:{(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester

Chemical Property of {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester

Chemical Property:

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Technology Process of {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester

There total 4 articles about {(S)-1-[2-Cyano-2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-indanol (25501-32-0) → {(S)-1-[2-Cyano-2-(triphenyl-λ5-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester (854001-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 85 °C

2: aq. LiOH / tetrahydrofuran

3: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.03.023

Reference yield:

(S)-2-((S)-Indan-1-yloxycarbonylamino)-hexanoic acid methyl ester (907562-44-1) → {(S)-1-[2-Cyano-2-(triphenyl-λ5-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester (854001-46-0)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. LiOH / tetrahydrofuran

2: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2005.03.023

Reference yield:

(S)-2-Isocyanato-hexanoic acid methyl ester (96789-62-7) → {(S)-1-[2-Cyano-2-(triphenyl-λ5-phosphanylidene)-acetyl]-pentyl}-carbamic acid (S)-indan-1-yl ester (854001-46-0)

Guidance literature:

Multi-step reaction with 3 steps

1: toluene / 85 °C

2: aq. LiOH / tetrahydrofuran

3: DMAP; EDC / CH₂Cl₂

With dmap; lithium hydroxide; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.03.023

upstream raw materials:

(S)-2-((S)-Indan-1-yloxycarbonylamino)-hexanoic acid

cyanomethylene triphenylphosphorane

(S)-2-((S)-Indan-1-yloxycarbonylamino)-hexanoic acid methyl ester

(S)-indanol

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