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25501-32-0

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25501-32-0 Usage

Uses

(S)?-?(+)?-?1-?Indanol is a building block used in pharmaceutical synthesis such as orally bioavailable GPR40 agonists such as DS-1558 used to stimulate insulin secretion.

Check Digit Verification of cas no

The CAS Registry Mumber 25501-32-0 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,5,5,0 and 1 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 25501-32:
(7*2)+(6*5)+(5*5)+(4*0)+(3*1)+(2*3)+(1*2)=80
80 % 10 = 0
So 25501-32-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H10O/c10-9-6-5-7-3-1-2-4-8(7)9/h1-4,9-10H,5-6H2/t9-/m0/s1

25501-32-0 Well-known Company Product Price

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  • Aldrich

  • (323128)  (S)-(+)-1-Indanol  99%

  • 25501-32-0

  • 323128-1G

  • 3,582.54CNY

  • Detail

25501-32-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name (1S)-2,3-dihydro-1H-inden-1-ol

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

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More Details:25501-32-0 SDS

25501-32-0Relevant articles and documents

Asymmetric transfer hydrogenation of ketonic substrates catalyzed by (η5-C5Me5)MCl complexes (M = Rh and Ir) of (1S, 2S)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine

Mashima, Kazushi,Abe, Tomoyuki,Tani, Kazuhide

, p. 1199 - 1200 (1998)

The rhodium and iridium (η5-C5Me5)MCl complexes (3a: M = Rh; 3b: M = Ir) of (1S,25)-N-(p-toluenesulfonyl)-1,2-diphenylethylenediamine were found to be catalyst precursors for asymmetric transfer hydrogenation of acetophenone, 2-acetonaphthone, 1-tetralone, and 1-indanone to give (S)-1-phenylethanol (90% ee), (S)-1-(2-naphthyl)ethanol (85% ee), (S)-1-tetralol (97% ee), and (S)-indanol (99% ee), respectively.

Designer Outer Membrane Protein Facilitates Uptake of Decoy Molecules into a Cytochrome P450BM3-Based Whole-Cell Biocatalyst

Karasawa, Masayuki,Shoji, Osami,Stanfield, Joshua Kyle,Suzuki, Kazuto,Yonemura, Kai

supporting information, (2021/12/16)

We report an OmpF loop deletion mutant, which improves the cellular uptake of external additives into an Escherichia coli whole-cell biocatalyst. Through co-expression of the OmpF mutant with wild-type P450BM3 in the presence of decoy molecules, the yield

Chiral salen - Ni (II) based spherical porous silica as platform for asymmetric transfer hydrogenation reaction and synthesis of potent drug intermediate montekulast

Shukla, Meenakshi,Barick,Salunke,Chandra, Sudeshna

, (2021/02/05)

Heterogeneous catalyst has an edge over homogeneous systems in terms of recyclability, activity, stability and recovery. Silica has evolved as a good support material in heterogeneous systems due to its stability and ability to get modified as per the end application. Herein, we report a novel chiral Ni-Schiff base derived catalyst and its immobilization into mesoporous silica which was synthesized by post-grafting process. The chiral catalyst demonstrated remarkably high catalytic activity, enantioselectivity (up to 99 % enantiomers excess) for heterogeneous asymmetric transfer hydrogenation of various ketones. The developed catalyst was characterized by Ultraviolet-visible spectroscopy (UV–vis), Fourier-Transform Infrared spectroscopy (FT-IR), X-ray Powder Diffraction (XRD), Brunauer-Emmett-Teller (BET isotherm), Scanning Electron Microscopy – Energy Dispersive X-ray Spectroscopy (SEM-EDX), High Resolution – Transmission Electron Microscopy (HR-TEM), Vibrating Sample Magnetometer (VSM), X-ray Photoelectron Spectroscopy (XPS) and elemental analysis. The catalyst could be recovered and reused for multiple consecutive runs without losing the enantioselectivity. The chiral catalyst was used in asymmetric transfer hydrogenation reaction for synthesizing enantiomerically pure drug intermediate Montekulast.

Enantioselective direct, base-free hydrogenation of ketones by a manganese amido complex of a homochiral, unsymmetrical P-N-P′ ligand

Seo, Chris S. G.,Tsui, Brian T. H.,Gradiski, Matthew V.,Smith, Samantha A. M.,Morris, Robert H.

, p. 3153 - 3163 (2021/05/25)

The use of manganese in homogeneous hydrogenation catalysis has been a recent focus in the pursuit of more environmentally benign base metal catalysts. It has great promise with its unique reactivity when coupled with metal-ligand cooperation of aminophosphine pincer ligands. Here, a manganese precatalyst Mn(P-N-P′)(CO)2, where P-N-P′ is the amido form of the ligand (S,S)-PPh2CHPhCHPhNHCH2CH2PiPr2, has been synthesized and used for base-free ketone hydrogenation. This catalyst shows exceptionally high enantioselectivity and good activity, with tolerance for base-sensitive substrates. NMR structural analysis of intermediates formed by the reaction of the amido complex with hydrogen under pressure identified a reactive hydride with an NOE contact with the syn amine proton. Computational analysis of the catalytic cycle reveals that the heterolytic splitting of dihydrogen across the MnN bond in the amido complex has a low barrier while the hydride transfer to the ketone is the turnover-limiting step. The pro-S transition state is found to be usually much lower in energy than the pro-R transition state depending on the ketone structure, consistent with the high (S) enantiomeric excess in the alcohol products. The energy to reach the transition state is higher for the distortion of the in-coming ketone than that of the hydride complex. In a one-to-one comparison with the similar iron catalyst FeH2(CO)(P-NH-P′), the manganese catalyst is found to have higher enantioselectivity, often over 95% ee, while the iron catalyst has higher activity and productivity. An explanation of these differences is provided on the basis of the more deformable iron hydride complex due to the smaller hydride ligands.

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