Antibiotic 704III

Base Information

Chemical Name:Antibiotic 704III
CAS No.:58801-71-1
Molecular Formula:C14H18O4
Molecular Weight:250.29
Hs Code.:
Mol file:58801-71-1.mol

Synonyms:(R)-methyl 5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-carboxylate;(+)-gregatin B;gregatin B;methyl {(R)-5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate;(R)-2-[(E,E)-hexa-1,3-dienyl]-4-(methoxycarbonyl)-2,5-dimethylfuran-3(2H)-one;

Suppliers and Price of Antibiotic 704III

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Antibiotic 704III

Chemical Property:

PSA：52.60000
LogP:2.31380

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Antibiotic 704III

There total 52 articles about Antibiotic 704III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1301680-12-5
2-[(1E)-but-1-en-1-yl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: methyl (E)-(5R)-5-(2-iodovinyl)-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-carboxylate

: 58801-71-1
methyl {(R)-5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 - 10 ℃; for 13h; Inert atmosphere;
DOI:10.1021/ol402472q

Reference yield: 78.0%

: 1402731-45-6
methyl (E,E)-(R)-4-acetoxy-4-methyl-3-oxodeca-5,7-dienoate

: 58801-71-1
methyl {(R)-5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate

: 1402731-59-2
methyl {(R)-5-[(1'E,3'Z)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate

Guidance literature:: With sodium hydrogencarbonate; In methanol; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/ejoc.201200207

Reference yield: 61.0%

: methyl (E)-(R)-4-hydroxy-4-methyl-3-oxodeca-5,7-dienoate

: 75-36-5
acetyl chloride

: 58801-71-1
methyl {(R)-5-[(E,E)-hexa-1,3-dienyl]-2,5-dimethyl-4-oxo-4,5-dihydrofuran-3-yl}carboxylate

Guidance literature:: methyl (E)-(R)-4-hydroxy-4-methyl-3-oxodeca-5,7-dienoate; With triethylamine; In dichloromethane; at 20 ℃; for 0.0833333h; Inert atmosphere;

acetyl chloride; In dichloromethane; at 20 ℃; for 1.08333h; Inert atmosphere;
DOI:10.1002/ejoc.201200207