1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Base Information

Chemical Name:1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane
CAS No.:308124-44-9
Molecular Formula:C₃₂H₅₃N₇O₉
Molecular Weight:679.814
Hs Code.:

1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Synonyms:1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

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Chemical Property of 1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

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Technology Process of 1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

There total 8 articles about 1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 294-90-6
1,4,7,10-tetraazacyclododecan

: 308124-43-8
5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

: 308124-44-9
1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: With potassium iodide; In tetrahydrofuran; at 40 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 308124-44-9
1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

3: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

4: 73 percent / KI / tetrahydrofuran / 40 °C

With dmap; hydrogen; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; 1: Acylation / 2: Hydrogenation / 3: Acylation / 4: Alkylation;

Reference yield:

: 926231-53-0
2-amino-1-(N-methylcarbamoylmethoxy)benzene

: 308124-44-9
1-{3-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)-4-[N,N-bis(ethoxycarbonylmethyl)amino]phenylcarbamoylmethyl}-1,4,7,10-tetraazacyclododecane

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / KI; Na₂HPO₄ / acetonitrile / Heating

2: 70 percent / NO₂BF₄ / acetonitrile / -20 - 20 °C

3: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

4: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

5: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

6: 73 percent / KI / tetrahydrofuran / 40 °C

With dmap; disodium hydrogenphosphate; nitronium tetrafluoborate; hydrogen; triethylamine; potassium iodide; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; chloroform; acetonitrile; 1: Alkylation / 2: Nitration / 3: Acylation / 4: Hydrogenation / 5: Acylation / 6: Alkylation;