5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

Base Information

Chemical Name:5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene
CAS No.:308124-43-8
Molecular Formula:C₂₄H₃₄ClN₃O₉
Molecular Weight:544.002
Hs Code.:

Synonyms:5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

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Chemical Property of 5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

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Technology Process of 5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

There total 7 articles about 5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 79-04-9
chloroacetyl chloride

: 308124-42-7
5-amino-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

: 308124-43-8
5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

Guidance literature:: With triethylamine; In diethyl ether; at -20 - 20 ℃;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 308124-43-8
5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

2: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

3: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

With dmap; hydrogen; triethylamine; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; chloroform; 1: Acylation / 2: Hydrogenation / 3: Acylation;

Reference yield:

: 446857-12-1
2-nitro-1-(N-methylcarbamoylmethoxy)benzene

: 308124-43-8
5-(β-chloroethanamido)-2-[N,N-bis(ethoxycarbonylmethyl)amino]-1-(N-methyl-N-tert-butoxycarbonylcarbamoylmethoxy)benzene

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd/C / ethanol / 2585.81 - 3102.97 Torr

2: 93 percent / KI; Na₂HPO₄ / acetonitrile / Heating

3: 70 percent / NO₂BF₄ / acetonitrile / -20 - 20 °C

4: 88 percent / Et₃N; DMAP / CH₂Cl₂ / 20 °C

5: 75 percent / H₂ / Pd/C / ethanol; CHCl₃ / 2585.81 - 3102.97 Torr

6: 80 percent / Et₃N / diethyl ether / -20 - 20 °C

With dmap; disodium hydrogenphosphate; nitronium tetrafluoborate; hydrogen; triethylamine; potassium iodide; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; chloroform; acetonitrile; 1: Hydrogenation / 2: Alkylation / 3: Nitration / 4: Acylation / 5: Hydrogenation / 6: Acylation;