(3R)-4-benzyloxy-3-methoxy-butanic acid

Base Information

Chemical Name:(3R)-4-benzyloxy-3-methoxy-butanic acid
CAS No.:472979-05-8
Molecular Formula:C₁₂H₁₆O₄
Molecular Weight:224.257
Hs Code.:

Synonyms:(3R)-4-benzyloxy-3-methoxy-butanic acid

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Chemical Property of (3R)-4-benzyloxy-3-methoxy-butanic acid

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Technology Process of (3R)-4-benzyloxy-3-methoxy-butanic acid

There total 4 articles about (3R)-4-benzyloxy-3-methoxy-butanic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 472979-65-0
(3R)-4-benzyloxy-3-methoxy-butyraldehyde

: 472979-05-8
(3R)-4-benzyloxy-3-methoxy-butanic acid

Guidance literature:: With sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide; In methanol; water; acetonitrile; at 10 ℃;
DOI:10.1021/ol026468j

Reference yield:

: 60656-87-3
benzyloxyacetoaldehyde

: 472979-05-8
(3R)-4-benzyloxy-3-methoxy-butanic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ti(i-PrO)4; 4 Angstroem molecular sieves; (R)-BINOL / CH₂Cl₂ / -20 °C

2.1: 94 percent / NaH / tetrahydrofuran / 20 °C

3.1: O₃ / CH₂Cl₂ / -78 °C

3.2: 86 percent / PPh₃ / CH₂Cl₂ / 20 °C

4.1: 98 percent / NaClO₂; KH₂PO₄; H₂O₂ / acetonitrile; methanol; H₂O / 10 °C

With titanium(IV) isopropylate; sodium chlorite; potassium dihydrogenphosphate; 4 A molecular sieve; dihydrogen peroxide; (R)-1,1'-Bi-2-naphthol; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ol026468j

Reference yield:

: 58931-16-1,88981-35-5,110339-28-1
(R)-1-benzyloxypent-4-en-2-ol

: 472979-05-8
(3R)-4-benzyloxy-3-methoxy-butanic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 94 percent / NaH / tetrahydrofuran / 20 °C

2.1: O₃ / CH₂Cl₂ / -78 °C

2.2: 86 percent / PPh₃ / CH₂Cl₂ / 20 °C

3.1: 98 percent / NaClO₂; KH₂PO₄; H₂O₂ / acetonitrile; methanol; H₂O / 10 °C

With sodium chlorite; potassium dihydrogenphosphate; dihydrogen peroxide; sodium hydride; ozone; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/ol026468j