472979-65-0Relevant academic research and scientific papers
Toward the total synthesis of disorazole A(1) and C(1): asymmetric synthesis of a masked southern segment.
Hartung, Ingo V,Niess, Barbara,Haustedt, Lars Ole,Hoffmann, H Martin R
, p. 3239 - 3242 (2007/10/03)
[reaction: see text] A highly convergent asymmetric synthesis of the masked southern segment of the antimitotic agent disorazole A(1) involves a Sonogashira coupling between a C1'-C10' enyne and a suitably protected C11'-C19' vinyl iodide. The central E,Z,Z-triene moiety is masked as a more stable ynediene.
