tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Base Information

Chemical Name:tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate
CAS No.:1092444-52-4
Molecular Formula:C₃₁H₄₉N₅O₅Si
Molecular Weight:599.846
Hs Code.:

Synonyms:tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Suppliers and Price of tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

There total 9 articles about tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1092444-50-2
(R)-tert-butyl benzyl(5-((1-((tert-butyldimethylsilyl)oxy)but-3-en-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

: 1092444-51-3
tert-butyl benzyl(5-(((2S,3S)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

: 1092444-52-4
tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; In acetonitrile; tert-butyl alcohol; at 25 ℃;
DOI:10.1021/jm100732t

Reference yield:

: 771510-25-9
3-isopropylpyrazolo[1,5-a]pyrimidine-5,7-diol

: 1092444-52-4
tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / 16 h / Heating / reflux

2.1: ethanol / 3 h / Heating / reflux

3.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

4.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

4.2: 12 h / 100 °C

5.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 14 - 18 h / 20 °C

With osmium(VIII) oxide; water; 4-methylmorpholine N-oxide; sodium t-butanolate; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; acetone; toluene; tert-butyl alcohol;

Reference yield:

: 625-28-5
Isovaleronitrile

: 1092444-52-4
tert-butyl benzyl(5-(((2S,3R)-1-((tert-butyldimethylsilyl)oxy)-3,4-dihydroxybutan-2-yl)amino)-3-iso-propylpyrazolo[1,5-a]pyrimidin-7-yl)carbamate

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.17 h / -78 °C

1.2: 16.5 h / -78 - 20 °C

1.3: pH 3

2.1: acetic acid; hydrazine / ethanol / 16 h / Heating / reflux

3.1: sodium / ethanol / 16 h / Heating / reflux

3.2: pH 3

4.1: trichlorophosphate / 16 h / Heating / reflux

5.1: ethanol / 3 h / Heating / reflux

6.1: dmap / tetrahydrofuran / 1.5 h / 20 °C

7.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 0.08 h

7.2: 12 h / 100 °C

8.1: osmium(VIII) oxide; water; 4-methylmorpholine N-oxide / acetone; tert-butyl alcohol / 14 - 18 h / 20 °C

With osmium(VIII) oxide; water; sodium; acetic acid; 4-methylmorpholine N-oxide; sodium t-butanolate; hydrazine; lithium diisopropyl amide; trichlorophosphate; dmap; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; acetone; toluene; tert-butyl alcohol;