625-28-5Relevant articles and documents
Facile dehydration of primary amides to nitriles catalyzed by lead salts: The anionic ligand matters
Ruan, Shixiang,Ruan, Jiancheng,Chen, Xinzhi,Zhou, Shaodong
, (2020/12/09)
The synthesis of nitrile under mild conditions was achieved via dehydration of primary amide using lead salts as catalyst. The reaction processes were intensified by not only adding surfactant but also continuously removing the only by-product, water from the system. Both aliphatic and aromatic nitriles can be prepared in this manner with moderate to excellent yields. The reaction mechanisms were obtained with high-level quantum chemical calculations, and the crucial role the anionic ligand plays in the transformations were revealed.
Oxime compound and the nitrile compound continuous synthesis of (by machine translation)
-
Paragraph 0035; 0036; 0037; 0041; 0042; 0044; 0045; 0049, (2018/10/02)
The invention discloses a aryloximes and continuous synthesis of nitrile compounds. The method comprises the following steps: continuously in the reactor in the continuous instantaneous generation free hydroxylamine, free hydroxylamine with the RCH2 CHO condensation reaction, to obtain the oxime; wherein R is straight or branched alkyl, substituted or non-substituted aryl group, a substituted or non-substituted heterocyclic or cyclic alkyl, [...] a step through the continuous programme dewatered to form a nitrile. The application of the technical scheme of the invention, continuous instant generating free hydroxylamine, avoids a great deal of free hydroxylamine to the process production risks, through the continuous reaction device to carry out the reaction, simplified neutralization in the prior art, extraction, concentration and the like, the production cost is reduced. And in the course of the reaction, the solvent can accomplish the complete recovery, three waste emissions can be greatly reduced, and post-processing operation and the reaction operation is simplified, the production cost is reduced and the cost of raw material, also improves the amplifying a producing process of the security. (by machine translation)
Direct synthesis of nitriles from aldehydes and hydroxylamine hydrochloride catalyzed by a HAP@AEPH2-SO3H Nanocatalyst
Masjed, Samane Memar,Akhlaghinia, Batool,Zarghani, Monireh,Razavi, Nasrin
, p. 33 - 43 (2017/01/18)
We describe an efficient method for the direct preparation of nitriles from aldehydes and hydroxylamine hydrochloride catalyzed by sulfonated nanohydroxyapatite functionalized by 2-aminoethyl dihydrogen phosphate (HAP@AEPH2-SO3H) as an eco-friendly and recyclable solid acid nanocatalyst. In this protocol the use of a solid acid nanocatalyst provides a green, useful, and rapid method for the preparation of nitriles in excellent yields. In addition, the notable feature of this methodolgy is that the synthesized nanocatalyst can be recovered and reused five times without any noticeable loss of efficiency.
