1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide

Base Information

Chemical Name:1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide
CAS No.:165072-87-7
Molecular Formula:C₂₂H₂₂N₂O₂
Molecular Weight:346.429
Hs Code.:
DSSTox Substance ID:DTXSID101147785

Synonyms:DTXSID101147785;1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide;165072-87-7

Suppliers and Price of 1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide

Chemical Property:

XLogP3:3.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:6
Exact Mass:346.168127949
Heavy Atom Count:26
Complexity:526

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(C2=CC=CC=C2N1C)C(=O)C(=O)N(CC=C)CC3=CC=CC=C3

Technology Process of 1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide

There total 2 articles about 1,2-Dimethyl-alpha-oxo-N-(phenylmethyl)-N-2-propen-1-yl-1H-indole-3-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 4383-22-6
Allylbenzylamine

: 117196-94-8
1,2-Dimethyl-α-oxo-1H-indole-3-acetyl chloride

: 165072-87-7
1,2-Dimethyl-α-oxo-N-(phenylmethyl)-N-2-propenyl-1H-indole-3-acetamide

Guidance literature:: With sodium hydroxide; In dichloromethane; Ambient temperature;
DOI:10.1021/jo00119a046

Reference yield:

: 875-79-6
1,2-dimethylindole

: 165072-87-7
1,2-Dimethyl-α-oxo-N-(phenylmethyl)-N-2-propenyl-1H-indole-3-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / diethyl ether / 0.5 h / 0 °C

2: 73 percent / 15percent aq. NaOH / CH₂Cl₂ / Ambient temperature

With sodium hydroxide; In diethyl ether; dichloromethane;
DOI:10.1021/jo00119a046