5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

Base Information

Chemical Name:5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide
CAS No.:1368806-62-5
Molecular Formula:C₃₈H₃₉N₃O₃S
Molecular Weight:617.812
Hs Code.:

Synonyms:5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

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Chemical Property of 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

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Technology Process of 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

There total 6 articles about 5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1368806-59-0
C₁₆H₂₁N₃O₂

: 75286-49-6,75368-95-5
S-trityl-2-mercaptopropionic acid

: 1368806-62-5
5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/cmdc.201100522

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1368806-62-5
5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

Guidance literature:: Multi-step reaction with 6 steps

1: N-chloro-succinimide; aluminum oxide / 40 °C / Microwave irradiation

2: triethylamine / tetrahydrofuran / 1 h / 70 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 4 h / 60 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

5: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

6: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With aluminum oxide; N-chloro-succinimide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/cmdc.201100522

Reference yield:

: 1368806-58-9
tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

: 1368806-62-5
5-methyl-3-phenylisoxazole-4-carboxylic acid [5-(2-tritylsulfanylpropionyl)aminopentyl]amide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 4 h / 20 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1002/cmdc.201100522