tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

Base Information

Chemical Name:tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate
CAS No.:1368806-58-9
Molecular Formula:C₂₁H₂₉N₃O₄
Molecular Weight:387.479
Hs Code.:

Synonyms:tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

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Chemical Property of tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

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Technology Process of tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

There total 4 articles about tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 1136-45-4
5-methyl-3-phenylisoxazol-4-carboxylic acid

: 51644-96-3
5-tert-butoxycarbonylamino-1-aminopentane

: 1368806-58-9
tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 20h;
DOI:10.1002/cmdc.201100522

Reference yield:

: 932-90-1,622-31-1,140461-24-1,140461-25-2,622-32-2
syn-benzaldehyde oxime

: 1368806-58-9
tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: N-chloro-succinimide; aluminum oxide / 40 °C / Microwave irradiation

2: triethylamine / tetrahydrofuran / 1 h / 70 °C / Microwave irradiation

3: water; sodium hydroxide / methanol / 4 h / 60 °C

4: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With aluminum oxide; N-chloro-succinimide; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/cmdc.201100522

Reference yield:

: 1143-82-4
ethyl 5-methyl-3-phenylisoxazole-4-carboxylate

: 1368806-58-9
tert-butyl 5-(5-methyl-3-phenylisoxazole-4-carbonylamino)pentylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: water; sodium hydroxide / methanol / 4 h / 60 °C

2: benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In methanol; dichloromethane;
DOI:10.1002/cmdc.201100522