2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

Base Information

Chemical Name:2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester
CAS No.:205638-48-8
Molecular Formula:C₂₉H₃₇NO₈
Molecular Weight:527.615
Hs Code.:

Synonyms:2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

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Chemical Property of 2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

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Technology Process of 2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

There total 9 articles about 2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

: 205638-46-6
2-(1-Benzyl-3-methoxycarbonyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

: 205638-48-8
2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

: 2-(1-Benzyl-3-hydroxymethyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

Guidance literature:: With diisobutylaluminium hydride; In 1,2-dimethoxyethane; toluene; at -78 ℃; for 0.166667h;
DOI:10.3987/com-97-7779

Reference yield:

: 99683-30-4
diethyl α-oxoadipate

: 205638-48-8
2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: 100 percent / H₂ / 10percent Pd-C / ethanol / 16 h / 1838.8 Torr

2: 100 percent / diisopropylamine / CHCl₃ / 1.5 h / Heating

3: 95 percent / 60percent NaH / toluene / 0.17 h / Heating

4: 88 percent / MS-5A / tetrahydrofuran / 240 h

5: 77 percent / NaOAc / benzene / 2 h / Heating

6: 81 percent / NaOMe / methanol / 0.67 h / Ambient temperature

7: 80 percent / K₂CO₃ / acetone / 2 h / Heating

8: 1.) 60percent NaH / 1.) dioxane, r.t., 1 h; 2.) dioxane, reflux, 45 min

9: 53 percent / 1M DIBALH / toluene; 1,2-dimethoxy-ethane / 0.17 h / -78 °C

With hydrogen; sodium methylate; sodium acetate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; ethanol; chloroform; acetone; toluene; benzene;
DOI:10.3987/com-97-7779

Reference yield:

: 133634-32-9
2-hydroxy-adipic acid diethyl ester

: 205638-48-8
2-(1-Benzyl-3-formyl-7-methoxymethoxy-2-oxo-2,5,6,7-tetrahydro-1H-[1]pyrindin-4-yl)-malonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1: 100 percent / diisopropylamine / CHCl₃ / 1.5 h / Heating

2: 95 percent / 60percent NaH / toluene / 0.17 h / Heating

3: 88 percent / MS-5A / tetrahydrofuran / 240 h

4: 77 percent / NaOAc / benzene / 2 h / Heating

5: 81 percent / NaOMe / methanol / 0.67 h / Ambient temperature

6: 80 percent / K₂CO₃ / acetone / 2 h / Heating

7: 1.) 60percent NaH / 1.) dioxane, r.t., 1 h; 2.) dioxane, reflux, 45 min

8: 53 percent / 1M DIBALH / toluene; 1,2-dimethoxy-ethane / 0.17 h / -78 °C

With sodium methylate; sodium acetate; sodium hydride; diisobutylaluminium hydride; potassium carbonate; diisopropylamine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; chloroform; acetone; toluene; benzene;
DOI:10.3987/com-97-7779