ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Base Information

Chemical Name:ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate
CAS No.:1355489-16-5
Molecular Formula:C₁₆H₁₄ClF₂NO₄
Molecular Weight:357.741
Hs Code.:

Synonyms:ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Suppliers and Price of ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

There total 3 articles about ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1196157-30-8
3-chloro-5-hydroxy-2-methoxypyridine

: 1355488-98-0
ethyl 4-(bromomethyl)-2,5,difluorobenzoate

: 1355489-16-5
ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 18h; Inert atmosphere;

Reference yield:

: 103877-80-1
2,5-difluoro-4-methyl-benzoic acid

: 1355489-16-5
ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sulfuric acid / 18 h / Reflux

2.1: N-Bromosuccinimide / dibenzoyl peroxide / 1,2-dichloro-ethane / 48 h / 70 °C

2.2: 1.5 h / 0 °C

3.1: potassium carbonate / acetone / 18 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; sulfuric acid; potassium carbonate; dibenzoyl peroxide; In 1,2-dichloro-ethane; acetone;

Reference yield:

: 1355488-96-8
ethyl 2,5-difluoro-4-methylbenzoate

: 1355489-16-5
ethyl 4-((5-chloro-6-methoxypyridin-3-yloxy)methyl)-2,5-difluorobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / dibenzoyl peroxide / 1,2-dichloro-ethane / 48 h / 70 °C

1.2: 1.5 h / 0 °C

2.1: potassium carbonate / acetone / 18 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; potassium carbonate; dibenzoyl peroxide; In 1,2-dichloro-ethane; acetone;