7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

Base Information

Chemical Name:7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine
CAS No.:1585145-48-7
Molecular Formula:C₂₇H₂₇Cl₂N₅O₂
Molecular Weight:524.45
Hs Code.:

Synonyms:7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

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Chemical Property of 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

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Technology Process of 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

There total 7 articles about 7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 571189-49-6
5-(4-methyl-piperazin-1-yl)pyridin-2-ylamine

: 1585145-78-3
3-chloro-7-(2,6-dichloro-3,5-dimethoxyphenyl)isoquinoline

: 1585145-48-7
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; XPhos; In toluene; tert-butyl alcohol; at 120 ℃; Inert atmosphere;

Reference yield:

: 657410-79-2
1-methyl-4-(6-nitro-pyridin-3-yl)-piperazine

: 1585145-48-7
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogen; palladium 10% on activated carbon / methanol / 12 h

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; caesium carbonate; XPhos; In methanol; toluene; tert-butyl alcohol;

Reference yield:

: 39856-50-3
5-bromo2-nitropyridine

: 1585145-48-7
7-(2,6-dichloro-3,5-dimethoxyphenyl)-N-[5-(4-methylpiperazin-1-yl)pyridin-2-yl]isoquinolin-3-amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate; tetra-(n-butyl)ammonium iodide / dimethyl sulfoxide / 18 h / 120 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 12 h

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; caesium carbonate / toluene; tert-butyl alcohol / 120 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; tetra-(n-butyl)ammonium iodide; potassium carbonate; caesium carbonate; XPhos; In methanol; dimethyl sulfoxide; toluene; tert-butyl alcohol;