N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Base Information

Chemical Name:N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine
CAS No.:133817-83-1
Molecular Formula:C₂₀H₃₆BrNOSi
Molecular Weight:414.501
Hs Code.:

Synonyms:N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Suppliers and Price of N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

There total 3 articles about N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 769-92-6
4-tert-Butylaniline

: 133817-83-1
N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Guidance literature:: Multi-step reaction with 4 steps

1: 9.28 g / Br₂, conc. HCl / H₂O / 3 h

2: 69 percent / conc. H₂SO₄, NaNO₂ / ethanol; benzene / 3 h / Heating

3: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h

4: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C

With 1H-imidazole; hydrogenchloride; sulfuric acid; bromine; tert.-butyl lithium; sodium nitrite; In ethanol; water; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00011a028

Reference yield:

: 129316-09-2
1,3-dibromo-5-t-butylbenzene

: 133817-83-1
N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h

2: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C

With 1H-imidazole; tert.-butyl lithium; In N,N-dimethyl-formamide;
DOI:10.1021/ja00011a028

Reference yield:

: 10546-67-5
2,6-dibromo-4-(tert-butyl)aniline

: 133817-83-1
N-(3-bromo-5-tert-butylphenyl)-N-(tert-butyldimethylsiloxy)-N-tert-butylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / conc. H₂SO₄, NaNO₂ / ethanol; benzene / 3 h / Heating

2: 1.) t-BuLi / 1.) THF, pentane, from -78 deg C to 0 deg C, 30 min, 2.) THF, pentane, from -78 deg C to RT, 1 h

3: 100 percent / imidazole / dimethylformamide / 12 h / 50 - 60 °C

With 1H-imidazole; sulfuric acid; tert.-butyl lithium; sodium nitrite; In ethanol; N,N-dimethyl-formamide; benzene;
DOI:10.1021/ja00011a028