Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

Base Information

Chemical Name:Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid
CAS No.:522612-29-9
Molecular Formula:C₁₈H₁₀F₂N₂O₃
Molecular Weight:340.286
Hs Code.:

Synonyms:Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

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Chemical Property of Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

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Technology Process of Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

There total 3 articles about Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 372-09-8
cyanoacetic acid

: 522612-13-1
5-fluoro-1-(4-fluorobenzyl)isatin

: 522612-29-9
Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

Guidance literature:: With triethylamine; In 1,4-dioxane; at 20 ℃;
DOI:10.1021/jm030762f

Reference yield:

: 443-69-6
5-fluoro-1H-indole-2,3-dione

: 522612-29-9
Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: 44 percent / dimethylformamide / 20 °C

2.1: 85 percent / Et₃N / dioxane / 20 °C

With sodium hydride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm030762f

Reference yield:

: 352-11-4
1-chloromethyl-4-fluorobenzene

: 522612-29-9
Cyano-[5-fluoro-1-(4-fluoro-benzyl)-2-oxo-1,2-dihydro-indol-(3E)-ylidene]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: NaH / dimethylformamide

1.2: 44 percent / dimethylformamide / 20 °C

2.1: 85 percent / Et₃N / dioxane / 20 °C

With sodium hydride; triethylamine; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm030762f