tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

Base Information

Chemical Name:tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate
CAS No.:1221179-01-6
Molecular Formula:C₂₇H₄₈N₂O₈SSi
Molecular Weight:588.838
Hs Code.:

Synonyms:tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

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Chemical Property of tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

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Technology Process of tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

There total 3 articles about tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 1221179-00-5
N-(3-((1R)-2-(2-hydroxyethylamino)-1-triethylsilyloxyethyl)phenyl)methanesulfonamide

: 1221179-01-6
tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.1021/acs.jmedchem.5b00638

Reference yield:

: 320728-11-8
N-benzyl-N-(3-((1R)-2-iodo-1-triethylsilyloxy-ethyl)phenyl)methanesulfonamide

: 1221179-01-6
tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: neat (no solvent) / 100 °C / Inert atmosphere

2: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 50 °C

3: triethylamine; dmap / tetrahydrofuran / 20 °C / Inert atmosphere

With dmap; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/acs.jmedchem.5b00638

Reference yield:

: 1221178-52-4
N-benzyl-N-(3-((1R)-2-(benzyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)methanesulfonamide

: 1221179-01-6
tert-butyl N-(3-((1R)-2-(tert-butoxycarbonyl(2-hydroxyethyl)amino)-1-triethylsilyloxyethyl)phenyl)-N-methylsulfonylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: 20% palladium hydroxide-activated charcoal; hydrogen / tetrahydrofuran; methanol / 50 °C

2: triethylamine; dmap / tetrahydrofuran / 20 °C / Inert atmosphere

With dmap; 20% palladium hydroxide-activated charcoal; hydrogen; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/acs.jmedchem.5b00638