(R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether

Base Information

• Chemical Name: (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether
• CAS No.: 84999-94-0
• Molecular Formula: C₁₉H₂₂O₂
• Molecular Weight: 282.382
• Mol file: 84999-94-0.mol

Synonyms:(R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether

Chemical Property of (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether

There total 4 articles about (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(R)-2-Methoxy-2-phenyl-propan-1-ol (69160-04-9) + Cinnamyl bromide (4392-24-9) → (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether (84999-94-0)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1246/cl.1982.1637

Reference yield:

(R)-Atrolactic acid (3966-30-1) → (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether (84999-94-0)

Guidance literature:

Multi-step reaction with 4 steps

2: NaH / dimethylformamide

3: LiAlH₄ / tetrahydrofuran

4: 90 percent / NaH / dimethylformamide

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1246/cl.1982.1637

Reference yield:

methyl R-(-)-atrolactate (13448-80-1,20731-95-7,67596-42-3,13448-81-2) → (R)-(-)-cinnamyl 2-methoxy-2-phenylpropyl ether (84999-94-0)

Guidance literature:

Multi-step reaction with 3 steps

1: NaH / dimethylformamide

2: LiAlH₄ / tetrahydrofuran

3: 90 percent / NaH / dimethylformamide

With lithium aluminium tetrahydride; sodium hydride; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1246/cl.1982.1637

upstream raw materials:

(R)-2-Methoxy-2-phenyl-propan-1-ol

Cinnamyl bromide

(R)-Atrolactic acid

methyl R-(-)-atrolactate

Downstream raw materials:

C₂₂H₂₈O₂

C₂₃H₃₀O₂

C₂₂H₂₆O₂

Acetic acid (S)-3-phenyl-heptyl ester