dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

Base Information

Chemical Name:dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate
CAS No.:84080-32-0
Molecular Formula:C₂₆H₃₅NO₇Si
Molecular Weight:501.652
Hs Code.:

Synonyms:dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

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Chemical Property of dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

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Technology Process of dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

There total 1 articles about dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 84080-31-9
dibenzyl 2-amino-2-(hydroxy-methoxycarbonylmethyl)malonate

: 84080-32-0
dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

Guidance literature:: With 1H-imidazole; In N,N-dimethyl-formamide; at 25 ℃; for 4h;
DOI:10.1002/hlca.19820650508

Reference yield:

: 84080-32-0
dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

: 1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-fumarate

Guidance literature:: Multi-step reaction with 9 steps

1: benzene / 18 h / Heating; Dean-Stark strap

2: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

3: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

4: pyridine / CH₂Cl₂ / 2 h

5: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

6: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

7: 50 percent / H₂ / Pd/C / ethyl acetate / 3 h / 25 °C / 2327.2 Torr

8: 70 percent / 10percent NaHCO₃ / ethanol / 1 h / Ambient temperature

9: 40 percent / 1,5-diazabicyclo<5.4.0>undec-5-ene (DBU), trimethylsilyl chloride / diethyl ether / 3 h / Heating

With pyridine; Wilkinson's catalyst; chloro-trimethyl-silane; dimethylsulfide; hydrogen sulfide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; 1,5-Diazabicyclo[5.4.0]undec-5-ene; palladium on activated charcoal; In diethyl ether; ethanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1002/hlca.19820650508

Reference yield:

: 84080-32-0
dibutyl 2-amino-2-<((t-butyl)dimethylsilyloxy)methoxycarbonyl-methyl>malonate

: 84080-49-9
1-methyl hydrogen 3-(2-oxo-3-phenylacetamido-1-azetidinyl)-2-<(t-butyl)dimethylsilyloxy-(methoxycarbonyl)methyl>succinate

Guidance literature:: Multi-step reaction with 8 steps

1: benzene / 18 h / Heating; Dean-Stark strap

2: NEt₃ / CH₂Cl₂ / 5 h / 25 °C

3: H₂S/NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

4: pyridine / CH₂Cl₂ / 2 h

5: 70 percent / 1.) O₃; 2.) (CH₃)2S / CH₂Cl₂ / 1.) -78 deg C, 2 h; 2.) up to RT, 2 h

6: 20 percent / tris(triphenylphosphine)rhodium chloride / benzene / 2 h / Heating

7: 50 percent / H₂ / Pd/C / ethyl acetate / 3 h / 25 °C / 2327.2 Torr

8: 70 percent / 10percent NaHCO₃ / ethanol / 1 h / Ambient temperature

With pyridine; Wilkinson's catalyst; dimethylsulfide; hydrogen sulfide; hydrogen; sodium hydrogencarbonate; ozone; triethylamine; palladium on activated charcoal; In ethanol; dichloromethane; ethyl acetate; benzene;
DOI:10.1002/hlca.19820650508