Proguanil hydrochloride

Base Information

• Chemical Name: Proguanil hydrochloride
• CAS No.: 637-32-1
• Molecular Formula: C11H16 Cl N5 . Cl H
• Molecular Weight: 290.195
• Hs Code.: 2925294500
• European Community (EC) Number: 211-283-7
• NSC Number: 758688
• UNII: R71Y86M0WT
• DSSTox Substance ID: DTXSID7047776
• NCI Thesaurus Code: C47690
• RXCUI: 142428
• ChEMBL ID: CHEMBL1201059
• Mol file: 637-32-1.mol

Synonyms:Bigumal;Chlorguanid;Chloriguane;Chloroguanide;Chloroguanide Hydrochloride;Hydrochloride, Chloroguanide;Hydrochloride, Proguanil;Paludrin;Paludrine;Proguanil;Proguanil Hydrochloride

Chemical Property of Proguanil hydrochloride

Chemical Property:

• Vapor Pressure: 1.07E-06mmHg at 25°C
• Melting Point: 249-2510C
• Boiling Point: 402.7oC at 760 mmHg
• Flash Point: 197.4oC
• PSA: 83.79000
• LogP: 4.06530
• Storage Temp.: -20°C Freezer
• Solubility.: acetonitrile: water: ~1mg/mL (60/40)
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 289.0861010
• Heavy Atom Count: 18
• Complexity: 292

Purity/Quality:

98%,99%, ^*data from raw suppliers

Chlorguanide Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 25
• Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)N=C(N)N=C(N)NC1=CC=C(C=C1)Cl.Cl
• Isomeric SMILES: CC(C)N=C(N)/N=C(\N)/NC1=CC=C(C=C1)Cl.Cl
• Recent ClinicalTrials: Quality of Life Study for Sickle Cell Patients Treated With Jobelyn (Sorghum Bicolor Extract)
• Recent EU Clinical Trials: Pharmacokinetic Interactions between Ciprofloxacin and Chloroquine / Proguanil Prophylaxis
• Uses: Chlorguanide Hydrochloride can be intended for use as an internal standard for the quantification of Proguanil by GC- or LC-mass spectrometry. Proguanil (chlorguanide) may be used in anti-parasitic protozoan drug development to study its pharmacokinetics, metabolism, safety, efficacy and methods of delivery as an antimalarial drug. Antimalarial

Technology Process of Proguanil hydrochloride

There total 1 articles about Proguanil hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

→ proguanil hydrochloride (637-32-1)

Guidance literature:

With hydrogenchloride; In butan-1-ol; for 15h; Reflux;

Reference yield:

rhodium(III) chloride tetrahydrate + proguanil hydrochloride (637-32-1) → {Rh(paludrine)2(NO2)2}(NO2) hexahydrate

Guidance literature:

With NaNO₂; NaClO₂; In ethanol; water;

Reference yield:

rhodium(III) chloride tetrahydrate + proguanil hydrochloride (637-32-1) → {Rh(paludrine)3}Cl4

Guidance literature:

With NaClO₂; In ethanol; water; pH:7;

Downstream raw materials:

{Os(ClC₆H₄C₂H₅N₅C₃H₇)2Br₂}⁽¹⁺⁾*Br^(1-)={Os(ClC₆H₄C₂H₅N₅C₃H₇)2Br₂}Br

{Os(ClC₆H₄C₂H₅N₅C₃H₇)2Cl₂}⁽¹⁺⁾*Cl^(1-)={Os(ClC₆H₄C₂H₅N₅C₃H₇)2Cl₂}Cl

Refernces