1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

Base Information

Chemical Name:1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one
CAS No.:142721-06-0
Molecular Formula:C₁₉H₁₅ClF₃NO₂
Molecular Weight:381.782
Hs Code.:

Synonyms:1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

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Technology Process of 1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

There total 8 articles about 1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 142720-98-7
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-3-(methylthio)indolin-2-one

: 142721-06-0
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

Guidance literature:: With deactivated Raney nickel (heated at reflux in acetone for 2 h); In ethanol; Ambient temperature;
DOI:10.1021/jo00043a044

Reference yield: 55.0%

: 142720-99-8
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-3-(methylthio)-1-(2-propynyl)indolin-2-one

: 142721-06-0
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

: 142721-07-1
5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methyl-1-(2-propynyl)indolin-2-one

Guidance literature:: With zinc; In acetic acid; for 1h; Heating;
DOI:10.1021/jo00043a044

Reference yield:

: 78068-85-6
3-chloro-4-fluoro benzotrifluoride

: 142721-06-0
1-allyl-5-<(2-chloro-α,α,α-trifluoro-p-tolyl)oxy>-3-methylindolin-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / K₂CO₃ / dimethylformamide / 66 h / 100 °C

2: 1) chlorine, 2) triethylamine / 1) CH₂Cl₂, -78 deg C, 5-10 min, 2) a) -78 deg C, 1-1.5 h, b) up to RT, 1-2 h

3: 49 percent / p-toluenesulfonic acid / toluene / Heating

4: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

5: 1) NaH / 1) DMSO, 20-30 min, 2) DMSO, 1-4 h

6: 73 percent / deactivated Raney nickel (heated at reflux in acetone for 2 h) / ethanol / Ambient temperature

With deactivated Raney nickel (heated at reflux in acetone for 2 h); chlorine; sodium hydride; potassium carbonate; triethylamine; toluene-4-sulfonic acid; In ethanol; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jo00043a044