methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

Base Information

Chemical Name:methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride
CAS No.:1403365-97-8
Molecular Formula:C₁₉H₂₁NO₂*ClH
Molecular Weight:331.842
Hs Code.:

Synonyms:methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

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Chemical Property of methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

Chemical Property:

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Technology Process of methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

There total 5 articles about methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403453-37-1
methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate

: 1403365-97-8
methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; Inert atmosphere;

Reference yield:

: 5728-52-9
(4-biphenylyl)acetic acid

: 1403365-97-8
methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetyl chloride / 0 - 20 °C / Inert atmosphere

2.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Inert atmosphere

3.1: dirhodium tetraacetate / toluene / 3 h / 20 °C / Inert atmosphere

4.1: ozone / dichloromethane / -78 °C

4.2: 2 h / 20 °C

5.1: titanium(IV) isopropylate / methanol / 16 h / 20 °C / Inert atmosphere

5.2: 2 h / Inert atmosphere

6.1: hydrogenchloride / diethyl ether / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; 4-acetamidobenzenesulfonyl azide; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; acetyl chloride; dirhodium tetraacetate; In methanol; diethyl ether; dichloromethane; toluene; acetonitrile;

Reference yield:

: 59793-29-2
methyl 2-(1,1'-biphenyl-4-yl)acetate

: 1403365-97-8
methyl 1-([1,1'-biphenyl]-4-yl)-2-((methylamino)methyl)cyclopropanecarboxylate hydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1.1: 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 0 - 20 °C / Inert atmosphere

2.1: dirhodium tetraacetate / toluene / 3 h / 20 °C / Inert atmosphere

3.1: ozone / dichloromethane / -78 °C

3.2: 2 h / 20 °C

4.1: titanium(IV) isopropylate / methanol / 16 h / 20 °C / Inert atmosphere

4.2: 2 h / Inert atmosphere

5.1: hydrogenchloride / diethyl ether / Inert atmosphere

With titanium(IV) isopropylate; hydrogenchloride; 4-acetamidobenzenesulfonyl azide; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; dirhodium tetraacetate; In methanol; diethyl ether; dichloromethane; toluene; acetonitrile;